Specific Brain Reorganization Underlying Superior Upper Limb Motor Function After Spinal Cord Injury: A Multimodal MRI Study
Specific Brain Reorganization Underlying Superior Upper Limb Motor Function After Spinal Cord Injury: A Multimodal MRI Study
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DOI：
10.1177/1545968321989347
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发表时间：
2021-01-29
影响因子：
4.2
通讯作者：
Nakazawa, Kimitaka
中科院分区：
文献类型：
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作者：
Nakanishi, Tomoya;Nakagawa, Kento;Nakazawa, Kimitaka
研究背景我们最近发现，完全性脊髓损伤（SCI）患者的上肢握力控制能力比正常人高。然而，这种现象的神经基础是unknown.<$ESTA研究旨在探讨更高的握力控制在大脑中的个人与SCI使用多模态磁共振成像（MRI）的神经基础。MethodsEight SCI科目和10个健全的科目进行手握力控制任务在10%，20%，和30%的最大自愿收缩功能磁共振成像（fMRI）。静息状态的功能磁共振成像和T1加权结构图像，以调查脑网络和结构的变化后sci.ResultsSCI的受试者表现出更高的握力稳定性比健全的受试者（P <0.05，校正），较小的激活在初级运动皮层（P <0.05，校正），和失活的视觉皮层（P <0.001，未校正）。此外，SCI受试者的上级顶叶和左侧初级运动皮层之间有更强的功能连接（P <0.001，未校正），以及双侧上级顶叶中较大的灰质体积（P < .001，未校正）结论脊髓损伤患者顶叶上级小叶的结构和功能重组可能是其高级功能障碍的神经基础。握力控制，并可能负责在这些人中观察到的初级运动皮层的较小激活。这些发现可能在神经康复领域的应用，以改善脊髓损伤后的完整肢体功能。
BackgroundWe recently discovered that individuals with complete spinal cord injury (SCI) have a higher grip force control ability in their intact upper limbs than able-bodied subjects. However, the neural basis for this phenomenon is unknown.ObjectiveThis study aimed to investigate the neural basis of the higher grip force control in the brains of individuals with SCI using multimodal magnetic resonance imaging (MRI).MethodsEight SCI subjects and 10 able-bodied subjects performed hand grip force control tasks at 10%, 20%, and 30% of their maximal voluntary contraction during functional MRI (fMRI). Resting-state fMRI and T1-weighted structural images were obtained to investigate changes in brain networks and structures after SCI.ResultsSCI subjects showed higher grip force steadiness than able-bodied subjects (P < .05, corrected), smaller activation in the primary motor cortex (P < .05, corrected), and deactivation of the visual cortex (P < .001, uncorrected). Furthermore, SCI subjects had stronger functional connectivity between the superior parietal lobule and the left primary motor cortex (P < .001, uncorrected), as well as larger gray matter volume in the bilateral superior parietal lobule (P < .001, uncorrected).ConclusionsThe structural and functional reorganization observed in the superior parietal lobule of SCI subjects may represent the neural basis underlying the observed higher grip force control, and is likely responsible for the smaller activation in the primary motor cortex observed in these individuals. These findings could have applications in the fields of neurorehabilitation for improvement of intact limb functions after SCI.