In vitro Maturation (IVM) of human oocytes
In vitro Maturation (IVM) of human oocytes
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DOI：
10.1007/s00404-013-3033-3
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发表时间：
2013-09
影响因子：
2.6
通讯作者：
T. Strowitzki
中科院分区：
文献类型：
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作者：
T. Strowitzki
体外成熟是一种辅助生殖技术，与标准IVF或ICSI相反，它几乎完全避免了激素刺激。未成熟卵母细胞将在卵母细胞采集后24小时内在体外完全成熟。该方法于90年代初引入，适用于卵巢过度刺激高危患者。结果几乎与标准技术相当。到目前为止，尚未发现胎儿畸形的风险增加。IVM是IVF中一种合适的替代方案，适用于确切定义的患者亚组，特别是PCOS患者，但仍然不能取代标准技术。
In vitro maturation is a technique of assisted reproduction which in contrast to standard IVF or ICSI almost fully avoids hormonal stimulation. Immature oocytes will be fully matured in vitro within 24 h after oocyte collection. The method was introduced in the early nineties and is indicated in patients at high risk for ovarian hyperstimulation. Results are almost comparable to standard techniques. Up to now no elevated risk for fetal malformations has been described. IVM is a suitable alternative in IVF for an exactly defined subgroup of patients, in particular patients with PCOS, but still does not replace standard techniques.