Cochlear nerve demyelination causes prolongation of wave I latency in ABR of the myelin deficient (md) rat
Cochlear nerve demyelination causes prolongation of wave I latency in ABR of the myelin deficient (md) rat
复制标题
DOI：
10.1016/j.heares.2003.12.019
复制
发表时间：
2004-05-01
期刊：
影响因子：
2.8
通讯作者：
Nojyo, Y
中科院分区：
文献类型：
--
作者：
Ito, T;Tokuriki, M;Nojyo, Y
在这项研究中，我们研究了听觉脑干反应（ABR），畸变产物耳声发射（DPOAEs）和耳蜗形态的髓鞘缺陷（md）大鼠，完全缺乏中央髓鞘，但没有周围髓鞘。ABR的Ⅱ-Ⅳ波潜伏期和Ⅰ波潜伏期均明显延长。蜗轴附近的耳蜗神经纤维在进入内耳道的中途失去了髓鞘。DPOAEs也减少在较低的频率的组合音。由于耳蜗顶回终末神经纤维穿过耳蜗神经中枢部，ABR Ⅰ波延长和DPOAE低频衰减可能主要来源于耳蜗神经中枢部分脱髓鞘和内听道的传出橄榄耳蜗束。(C)2004 Elsevier B. V.保留所有权利。
In this study, we examined the auditory brainstem responses (ABRs), distortion product of otoacoustic emissions (DPOAEs) and cochlear morphology of the myelin deficient (md) rat, which completely lacks central myelin but not peripheral myelin. ABRs showed a marked prolongation not only wave II-IV latencies but also wave I latency. Cochlear nerve fibers near the modiolus lost their myelin halfway into the internal auditory canal. DPOAEs also decreased at a lower frequency of the combined tone. Since nerve fibers ending at the apical turn of the cochlea passed through central portion of the cochlear nerve, wave I prolongation of ABRs and decrease of DPOAEs at a lower frequency might originate mainly from the demyelinated CNS part of the cochlear nerve and efferent olivocochlear bundle in the internal auditory canal. (C) 2004 Elsevier B.V. All rights reserved.