Tumors as organs: complex tissues that interface with the entire organism.
Tumors as organs: complex tissues that interface with the entire organism.
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DOI：
10.1016/j.devcel.2010.05.012
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发表时间：
2010-06-15
影响因子：
11.8
通讯作者：
Werb, Zena
中科院分区：
文献类型：
--
作者：
Egeblad, Mikala;Nakasone, Elizabeth S.;Werb, Zena
实体瘤不仅仅是癌细胞的克隆。相反，它们是由多种细胞类型和细胞外基质组成的异常器官。肿瘤发展的某些方面类似于器官发育中的过程，而其他方面更类似于组织重塑。一些微环境，特别是那些与组织损伤相关的微环境，有利于突变细胞的发展，而另一些则限制它。癌细胞还可以指示周围组织发生变化，促进恶性肿瘤的发生。了解癌细胞与其周围环境相互作用的复杂方式，无论是在肿瘤器官中局部还是在整个身体中全身，都对有效的癌症预防和治疗具有重要意义。
Solid tumors are not simply clones of cancer cells. Instead, they are abnormal organs composed of multiple cell types and extracellular matrix. Some aspects of tumor development resemble processes seen in developing organs, while others are more akin to tissue remodeling. Some microenvironments, particularly those associated with tissue injury, are favorable for progression of mutant cells while others restrict it. Cancer cells can also instruct surrounding tissues to undergo changes that promote malignancy. Understanding the complex ways in which cancer cells interact with their surroundings, both locally in the tumor organ and systemically in the body as a whole, has implications for effective cancer prevention and therapy.
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DOI：
10.1073/pnas.0503039102
发表时间：
2005-10-11
影响因子：
11.1
作者：
Borrello, MG;Alberti, L;Pierotti, MA
通讯作者：
Pierotti, MA
影响因子：
10.5
作者：
Coussens, LM;Raymond, WW;Hanahan, D
通讯作者：
Hanahan, D
影响因子：
15.9
作者：
Acharyya, S;Ladner, KJ;Guttridge, DC
通讯作者：
Guttridge, DC
影响因子：
20.3
作者：
Camerer, E;Qazi, AA;Coughlin, SR
通讯作者：
Coughlin, SR
影响因子：
3.1
作者：
AUSPRUNK, DH;FOLKMAN, J
通讯作者：
FOLKMAN, J