EXPERIMENTAL SHIGELLA INFECTIONS - CHARACTERISTICS OF A FATAL INFECTION PRODUCED IN GUINEA PIGS
EXPERIMENTAL SHIGELLA INFECTIONS - CHARACTERISTICS OF A FATAL INFECTION PRODUCED IN GUINEA PIGS
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DOI：
10.1128/jb.75.5.604-610.1958
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发表时间：
1958-01-01
影响因子：
3.2
通讯作者：
SCHNEIDER, H
中科院分区：
文献类型：
--
作者：
FORMAL, SB;DAMMIN, GJ;SCHNEIDER, H
口服福氏志贺菌 2a 培养物的哈特利品系豚鼠产生致命性肠道感染，并伴有结肠溃疡性病变。为了实现这一目标，首先需要让动物禁食四天，并在攻击暂停前给予碳酸钙，并在攻击暂停后给予鸦片。接受这种治疗的动物在口服福氏链球菌 2a（LD50 约为 106 至 107 个细菌）后死亡，但在超过 10° 的大肠杆菌细胞剂量下仍能存活。描述了感染的一些特征，并给出了死于感染的动物肠道损伤的情况。
A fatal enteric infection with ulcerative lesions in the colon was produced in Hartley strain guinea pigs with an orally-administered culture of Shigella flexneri 2a. To accomplish this, it was first necessary to deprive the animals of food for four days and to administer calcium carbonate before and opium following the challenge suspension. Animals receiving this treatment succumb following oral challenges of S. flexneri 2a (LD50 approximately 106 to 107 bacteria),but survive doses in excess of 10[degree] cells of Escherichia coli. Some characteristics of the infection are described and account of the intestinal lesions in animals succumbing to the infection is given.