Relationship between brachial-ankle pulse wave velocity and cognitive function in an elderly community-dwelling population with metabolic syndrome
Relationship between brachial-ankle pulse wave velocity and cognitive function in an elderly community-dwelling population with metabolic syndrome
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DOI：
10.1016/j.archger.2008.07.004
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发表时间：
2009-07-01
影响因子：
4
通讯作者：
Lee, Ae Young
中科院分区：
文献类型：
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作者：
Kim, Ye-Sung;Kim, Dae-Hyun;Lee, Ae Young
动脉僵硬(AS)和代谢综合征(MS)可能与老年人认知功能低下有关。然而，很少有研究在健康的社区老年人口中评估这种关系。我们的目的是评估脉搏波速度(PWV)和认知功能之间的关系，并了解这种关系是否受到MS的存在的影响。我们的研究人群是韩国金山省的社区健康人。370名无脑血管病史的受试者接受了韩国版简易精神状态检查(K-MMSE)的评估，并测量了臂踝PWV(BaPWV)。测量baPWV与认知状态和多发性硬化症疗效的相关性。60岁以上MS患者PWV与认知功能呈负相关(r=-0.38，P<0.05)。受试者工作特征曲线以1800.8 cm/S为界值，敏感性为67%，特异性为78%。老龄化(60岁以上)和多发性硬化症的存在可能会影响老年人群中认知功能的协同性下降。BaPWV可作为老年健康社区居住人口认知衰退的有用预测指标。(C)2008 Elsevier爱尔兰有限公司。
Arterial stiffness (AS) and metabolic syndrome (MS) may correlate with poor cognitive function in elderly people. However, few studies have evaluated this relationship in a healthy, community-dwelling elderly population. Our aim was to evaluate a relationship between the AS measured by pulse wave velocity (PWV) and cognitive function and to know whether the relationship is influenced by the presence of MS. Our study population was community-dwelling healthy people in Geumsan province, Republic of Korea. A total of 370 participants without a history of cerebrovascular disease were evaluated with the Korean version of the mini-mental state examination (K-MMSE) and have measured the brachial-ankle PWV (baPWV). Correlation between baPWV and cognitive status and effect of MS were measured. Negative correlation between PWV and cognitive function was found in the older subjects (60 years of age) with MS (r = -0.38: p < 0.05). In the receiver operating characteristic (ROC) curve, the cut-off score was 1800.8 cm/s with 67% sensitivity and 78% specificity. Aging(older than 60 years) and the presence of MS may affect synergistically cognitive decline in the elderly population. The baPWV can be a useful predictor for cognitive decline in elderly healthy community-dwelling population with MS. (C) 2008 Elsevier Ireland Ltd. All rights reserved.