Evidence that nigral substance P controls the activity of the nigrotectal GABAergic pathway.
Evidence that nigral substance P controls the activity of the nigrotectal GABAergic pathway.
复制标题
有证据表明黑物质 P 控制黑质顶盖 GABA 能途径的活性。
DOI：
10.1016/0006-8993(84)90993-4
复制
发表时间：
1984
期刊：
影响因子：
2.9
通讯作者：
Gale,K
中科院分区：
文献类型：
--
作者：
Melis,MR;Gale,K
The unilateral intranigral application of either of two substance P (SP) analogs with antagonist properties ([dPro2,d-Phe7,d-Trp9]-SP and [d-Pro2,d-Trp7,9]-SP) induced a significant (37%) decrease in GABA turnover in the target region of the nigrotectal projections, namely the deep layers of the superior colliculus in the homolateral hemisphere, and was without any effect in the superficial layers. This action was not prevented by coinjection of the GABA antagonist bicuculline-methiodide. There was no effect of these SP analogs on GABA turnover in the deep layers of superior colliculus when they were microinjected in the ipsilateral median forebrain bundle or in the contralateral substantia nigra. These results are consistent with the proposal that nigral SP exerts a tonic excitatory action on efferent GABAergic projections from pars reticulata of substantia nigra.
