New developments in the staging of melanoma.
New developments in the staging of melanoma.
复制标题
黑色素瘤分期的新进展。
DOI：
10.1080/07357900500202887
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发表时间：
2005
影响因子：
2.4
通讯作者：
Nelson,MarkA
中科院分区：
文献类型：
--
作者：
Baruch,AmyC;Shi,Jiaqi;Feng,Yongmei;Nelson,MarkA
随着黑色素瘤发病率的增加，寻找新的分期技术可能提供重要的预后信息，并有助于发现早期转移性疾病。分子技术的应用可能为这方面的研究提供强有力的新工具。本文综述了传统RT-PCR、cDNA阵列和蛋白质组学在人类黑色素瘤研究中的最新发现。本综述中讨论的分子工具表明，全局转录和蛋白质分析不仅有助于黑色素瘤的分期，而且可能在改善这种疾病的诊断和治疗方面具有很大的希望。
As the incidence of melanoma increases, so does the search for new staging techniques that may provide important prognostic information and aid in the detection of early metastatic disease. The application of molecular techniques may provide powerful new tools in this search. This review summarizes recent findings obtained by means of conventional RT-PCR, cDNA arrays, and proteomics in the investigation of human melanoma. The molecular tools discussed in this review demonstrate how global transcript and protein analysis might contribute not only to the staging of melanoma, but may hold great promise in improving the diagnosis and treatment of this disease.