Dental and Nondental Stem Cell Based Regeneration of the Craniofacial Region: A Tissue Based Approach.
Dental and Nondental Stem Cell Based Regeneration of the Craniofacial Region: A Tissue Based Approach.
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DOI：
10.1155/2016/8307195
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发表时间：
2016
影响因子：
4.3
通讯作者：
Song B
中科院分区：
文献类型：
--
作者：
Hughes D;Song B
对于那些受到创伤、疾病或病理发育状况影响的人，颅面重建可能是一种必要的治疗方法。干细胞治疗和组织工程的使用显示出作为未来治疗方式的巨大潜力。目前在文献中，有各种各样的已发表的实验研究，利用可用的不同干细胞类型和过多的可用支架材料。本文综述了不同的干细胞来源及其独特的特性，以期为个体颅面组织的再生提供一种理想的细胞来源。目前，对干细胞治疗的理解和临床应用仍处于起步阶段，有许多挑战需要克服。尽管如此，该领域显示出巨大的容量，毫无疑问将被用于未来颅面再生的临床治疗。
Craniofacial reconstruction may be a necessary treatment for those who have been affected by trauma, disease, or pathological developmental conditions. The use of stem cell therapy and tissue engineering shows massive potential as a future treatment modality. Currently in the literature, there is a wide variety of published experimental studies utilising the different stem cell types available and the plethora of available scaffold materials. This review investigates different stem cell sources and their unique characteristics to suggest an ideal cell source for regeneration of individual craniofacial tissues. At present, understanding and clinical applications of stem cell therapy remain in their infancy with numerous challenges to overcome. In spite of this, the field displays immense capacity and will no doubt be utilised in future clinical treatments of craniofacial regeneration.