Phenolic Acid-based Poly(anhydride-esters) as Antioxidant Biomaterials.
Phenolic Acid-based Poly(anhydride-esters) as Antioxidant Biomaterials.
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作为抗氧化生物材料的酚酸基聚（酸酐酯）。
DOI：
10.1002/mabi.201500244
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发表时间：
2016
影响因子：
4.6
通讯作者：
Uhrich,KathrynE
中科院分区：
文献类型：
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作者：
Prudencio,Almudena;Faig,JonathanJ;Song,MinJung;Uhrich,KathrynE
采用溶液聚合法制备了具有抗氧化性能的天然无毒酚酸，即丁香酸和香草酸，组成的聚酸酐酯。对聚合物及其前驱体的理化性质进行了表征，包括聚合物分子量和热性能。体外释放研究表明，聚合物的水解降解受酚酸的相对疏水性和甲氧基取代度的影响。此外，通过2,2‐二苯基‐1‐苦基肼测定，发现释放的酚酸相对于游离酚酸保持抗氧化能力。用L929成纤维细胞在含聚合物培养基中评估聚合物细胞毒性；在较低的浓度下，聚合物获得了良好的细胞形态和高的成纤维细胞增殖。这些聚合物提供非细胞毒性水平的天然抗氧化剂，这在局部抗氧化治疗中是有效的。
Poly(anhydride‐esters) comprised of naturally occurring, non‐toxic phenolic acids, namely syringic and vanillic acid, with antioxidant properties were prepared via solution polymerization methods. Polymer and polymer precursor physiochemical properties were characterized, including polymer molecular weight and thermal properties. In vitro release studies illustrated that polymer hydrolytic degradation was influenced by relative hydrophobicity and degree of methoxy substitution of the phenolic acids. Further, the released phenolic acids were found to maintain antioxidant potency relative to free phenolic acid controls as determined by a 2,2‐diphenyl‐1‐picrylhydrazyl assay. Polymer cytotoxicity was assessed with L929 fibroblasts in polymer‐containing media; appropriate cell morphology and high fibroblast proliferation were obtained for the polymers at the lower concentrations. These polymers deliver non‐cytotoxic levels of naturally occurring antioxidants, which could be efficacious in topical delivery of antioxidant therapies.