Increased Sensitivity of the Circadian System to Light in Early/Mid-Puberty
Increased Sensitivity of the Circadian System to Light in Early/Mid-Puberty
复制标题
DOI：
10.1210/jc.2015-2775
复制
发表时间：
2015-11-01
影响因子：
5.8
通讯作者：
Carskadon, Mary A.
中科院分区：
文献类型：
--
作者：
Crowley, Stephanie J.;Cain, Sean W.;Carskadon, Mary A.
背景：青春期后期的特点是睡眠时间延迟，这部分是由昼夜节律计时系统的延迟转变驱动的。这项研究探讨了昼夜节律系统对光的敏感性（昼夜节律系统的主要诱发刺激）在青春期前至青春期中期和青春期后期至青春期后青少年之间是否存在差异。目的：该研究旨在确定青春期对人体昼夜节律系统对光的敏感性的影响。方法：在38名青春期前至青春期中期（9.1-14.7岁）和29名青春期后期至青春期后（11.5-15.9岁）青少年中评估了褪黑激素对低和中等光照水平的抑制。他们在连续的夜晚接受了1小时的四种光照水平：大约0.1（接近黑暗的基线条件），15，150和500勒克斯。一组在11：00 PM开始接受晚间光照（n = 39）;第二组在3：00 AM开始接受早晨光照（n = 28）。唾液褪黑激素每30分钟取样一次。在个体内，相对于0.1勒克斯设置中未抑制的基线水平，计算15、150和500勒克斯的褪黑激素抑制。青春期前至中期组表现出显着更大的褪黑激素抑制到15勒克斯（9.2 +/- 20.5%），150勒克斯与青春期后期至后组相比，在夜间光照下，500勒克斯（26.0 +/- 17.7%）和500勒克斯（36.9 +/- 11.4%）组（分别为-5.3 +/-17.7%，12.5 +/-17.3%和23.9 +/-21.7%; P
Context: Late adolescence is marked by a delay in sleep timing, which is partly driven by a delay shift of the circadian timing system. This study examined whether the sensitivity of the circadian system to light-the primary entraining stimulus to the circadian system-differs between pre-to mid-pubertal and late to postpubertal adolescents.Objective: The study was designed to determine the influence of puberty on the sensitivity of the circadian system to light in humans.Methods: Melatonin suppression to low and moderate light levels was assessed in 38 pre-to mid-pubertal (9.1-14.7 years) and 29 late to postpubertal (11.5-15.9 years) adolescents. They received 1 hour of four light levels on consecutive nights: approximately 0.1 (near-dark baseline condition), 15, 150, and 500 lux. One group received evening light beginning at 11: 00 PM (n = 39); a second group received morning light beginning at 3: 00 AM (n = 28). Salivary melatonin was sampled every 30 minutes. Melatonin suppression for 15, 150, and 500 lux was calculated relative to unsuppressed baseline levels in the 0.1 lux setting, within individuals.Results: The pre-to mid-pubertal group showed significantly greater melatonin suppression to 15 lux (9.2 +/- 20.5%), 150 lux (26.0 +/- 17.7%), and 500 lux (36.9 +/- 11.4%) during evening light exposure compared to the late to postpubertal group (-5.3 +/- 17.7%, 12.5 +/- 17.3%, and 23.9 +/- 21.7%, respectively; P