TNIP1-mediated TNF-α/NF-κB signalling cascade sustains glioma cell proliferation
TNIP1-mediated TNF-α/NF-κB signalling cascade sustains glioma cell proliferation
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TNIP1 介导的 TNFα/NFαB 信号级联维持神经胶质瘤细胞增殖
DOI：
10.1111/jcmm.14760
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发表时间：
2019-11-05
影响因子：
5.3
通讯作者：
Zhao, Ninghui
中科院分区：
文献类型：
--
作者：
Lei, Qingchun;Gu, Huan;Zhao, Ninghui
胶质瘤是中枢神经系统的一种恶性肿瘤，发病率高，预后差。尽管TNIP1和肿瘤坏死因子-α/核因子-kappaB轴在免疫疾病和炎症反应中起关键作用，但它们在胶质瘤中的关系和作用尚不清楚。在这里，我们发现在胶质瘤组织中有高水平的TNIP1和肿瘤坏死因子-α/核因子-kappaB。肿瘤坏死因子-α可激活胶质瘤细胞的增殖，并对肿瘤坏死因子受体拮抗剂表现出极高的敏感性。此外，TNIP1的缺失消除了导致I-kappa B降解和NF-kappa B核移位的A20复合体，从而消除了肿瘤坏死因子α诱导的胶质瘤细胞增殖。因此，我们的研究揭示了TNIP1介导的肿瘤坏死因子-α/核因子-kappa B轴在胶质瘤细胞增殖中的重要作用，并为胶质瘤的病理和诊断提供了新的视角。
As a malignant tumour of the central nervous system, glioma exhibits high incidence and poor prognosis. Although TNIP1 and the TNF-alpha/NF-kappa B axis play key roles in immune diseases and inflammatory responses, their relationship and role in glioma remain unknown. Here, we revealed high levels of TNIP1 and TNF-alpha/NF-kappa B in glioma tissue. Glioma cell proliferation was activated with TNF-alpha treatment and showed extreme sensitivity to the TNF receptor antagonist. Furthermore, loss of TNIP1 disbanded the A20 complex responsible for I kappa B degradation and NF-kappa B nucleus translocation, and consequently erased TNF alpha-induced glioma cell proliferation. Thus, our investigation uncovered a vital function of the TNIP1-mediated TNF-alpha/NF-kappa B axis in glioma cell proliferation and provides novel insight into glioma pathology and diagnosis.