Delay-dependent involvement of the rat entorhinal cortex in habituation to a novel environment
Delay-dependent involvement of the rat entorhinal cortex in habituation to a novel environment
复制标题
DOI：
10.1016/j.nlm.2008.03.001
复制
发表时间：
2008-07-01
影响因子：
2.7
通讯作者：
Save, Etienne
中科院分区：
文献类型：
--
作者：
Van Cauter, Tiffany;Poucet, Bruno;Save, Etienne
越来越多的证据表明，内嗅皮层（EC）参与了长期记忆形成的记忆操作。由于内嗅损伤大鼠在延迟匹配和不匹配样本任务中出现长时间延迟，因此有人提出EC有助于短期记忆信息的维持。在本研究中，我们提出了这样的时间限制作用是否也适用于在新环境中学习复杂的空间信息。因此，我们研究了EC损伤对物体探索任务中习惯化的影响，在连续的会话之间施加4分钟或10分钟的延迟。ec损伤大鼠在延迟10分钟而不是4分钟时表现出适应缺陷。在习惯化之后，对空间变化（物体配置）和非空间变化（新物体）的反应也被检查。ec损伤大鼠在检测空间变化方面受损，但能够检测非空间变化，无论延迟如何。总的来说，结果表明，EC参与了在短期记忆中维持大量新颖的多维信息，从而促进了长期记忆的形成。切换到新颖性检测模式将允许动物快速适应环境变化。在这种模式下，电子商务优先处理空间信息，而不是非空间信息。(C) 2008爱思唯尔公司版权所有。
Evidence has accumulated that the entorhinal cortex (EC) is involved in memory operations underlying formation of a long-term memory. Because entorhinal-lesioned rats are impaired for long delays in delayed matching and non-matching to sample tasks, it has been proposed that EC contributes to the maintenance of information in short-term memory. In the present study, we asked whether such a time-limited role applies also when learning complex spatial information in a novel environment. We therefore examined the effects of EC lesions on habituation in an object exploration task in which a delay of either 4 min or 10 min is imposed between successive sessions. EC-lesioned rats exhibited a deficit in habituation at 10 min but not 4 min delays. Following habituation, reactions to spatial change (object configuration) and non-spatial change (novel object) were also examined. EC-lesioned rats were impaired in detecting the spatial change but were able to detect a non-spatial change, irrespective of the delay. Overall, the results suggest that EC is involved in maintaining a large amount of novel, multidimensional information in short-term memory therefore enabling formation of long-term memory. Switching to a novelty detection mode would then allow the animal to rapidly adapt to environmental changes. In this mode, EC would preferentially process spatial information rather than non-spatial information. (C) 2008 Elsevier Inc. All rights reserved.