INHIBITION OF ENDOTHELIAL-CELL PROLIFERATION BY TYPE BETA-TRANSFORMING GROWTH-FACTOR - INTERACTIONS WITH ACIDIC AND BASIC FIBROBLAST GROWTH-FACTORS
INHIBITION OF ENDOTHELIAL-CELL PROLIFERATION BY TYPE BETA-TRANSFORMING GROWTH-FACTOR - INTERACTIONS WITH ACIDIC AND BASIC FIBROBLAST GROWTH-FACTORS
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DOI：
10.1016/0006-291x(86)90305-0
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发表时间：
1986-07-16
影响因子：
3.1
通讯作者：
DURKIN, T
中科院分区：
文献类型：
--
作者：
BAIRD, A;DURKIN, T
TGF.β。是体外血管和毛细血管内皮细胞上酸性和碱性 FGF 增殖活性的有效抑制剂（ED50 约 10-11 M）。细胞生长的抑制是剂量依赖性的并且是非竞争性相互作用的特征。结果表明TGF.beta。 TGF.β和FGF可以在细胞水平上相互作用以调节生长，并且表明在体外和体内观察到的FGF的许多生物活性（即血管生成、细胞生长、细胞分化）可以通过TGF.β的存在来调节。以及局部细胞环境中的相关蛋白质（即抑制）。 TGF.beta 的可能身份。讨论了粗提物体外测定中检测到的内皮细胞生长抑制剂。
TGF.beta. is a potent (ED50 .apprx. 10-11 M) inhibitor of the proliferative activities of both acidic and basic FGF on vascular and capillary endothelial cells in vitro. The inhibition of cell growth is dose-dependent and characteristic of a non-competitive interaction. The results demonstrate that TGF.beta. and FGF can interact at the cellular level to modulate growth and suggest that many of the biological activities of FGF observed in vitro and in vivo (ie angiogenesis, cell growth, cell differentiation) may be regulated by the presence of TGF.beta. and related proteins (ie inhibition) in the local cellular milieu. The possible identity of TGF.beta. with the inhibitors of endothelial cell growth detected in in vitro assays of crude extracts is discussed.