Oral Administration of D-aspartate, but not of L-aspartate, Reduces Food Intake in Chicks
Oral Administration of D-aspartate, but not of L-aspartate, Reduces Food Intake in Chicks
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DOI：
10.2141/jpsa.0120116
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发表时间：
2013-04-01
影响因子：
1.5
通讯作者：
Furuse, Mitsuhiro
中科院分区：
文献类型：
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作者：
Erwan, Edi;Tomonaga, Shozo;Furuse, Mitsuhiro
在本研究中，我们确定了口服L-和D-天冬氨酸（L-Asp和D-Asp）对给药后2小时内食物摄入的影响，以及其对大脑和血浆中L-和D-Asp浓度的影响。给小鸡口服不同水平（0、3.75、7.5和15mmol/kg体重）的L-Asp（实验1）和D-Asp（实验2）。给予数剂量的 L-Asp 线性增加血浆中 L-Asp 的浓度，但不增加 D-Asp 的浓度。口服L-天冬氨酸在一定程度上改变了端脑中的L-和D-天冬氨酸水平，但不改变间脑中的L-和D-天冬氨酸水平。然而，食物摄入量并没有随 L-Asp 剂量的变化而发生显着变化。另一方面，D-Asp 在给药后 2 小时内强烈且剂量依赖性地抑制食物摄入。口服 D-Asp 明显增加血浆和间脑中的 D-Asp 水平，但未检测到 L-Asp 的显着变化。 L-或D-天冬氨酸给药对脑单胺含量的影响很小。我们得出结论，D-Asp 可能充当间脑中的厌食因子。
In the present study, we determined the effects of oral administration of L- and D-aspartate (L-Asp and D-Asp) on food intake over a period of 2 h after the administration, as well as its effects on the concentration of L- and D-Asp in the brain and plasma. Chicks were orally administered different levels (0, 3.75, 7.5 and 15 mmol/kg body weight) of L-Asp (Experiment 1) and D-Asp (Experiment 2). Administration of several doses of L-Asp linearly increased the concentration of L-Asp, but not of D-Asp, in plasma. Oral L-Asp somewhat modified the levels of L- and D-Asp levels in the telencephalon, but not in the diencephalon. However, food intake was not significantly changed with doses of L-Asp. On the other hand, D-Asp strongly and dose-dependently inhibited food intake over a period of 2 h after the administration. Oral D-Asp clearly increased D-Asp levels in the plasma and diencephalon, but no significant changes in L-Asp were detected. Brain monoamine contents were only minimally influenced by L- or D- Asp administration. We conclude that D-Asp may act as an anorexigenic factor in the diencephalon.