Serum levels and renal deposition of C1q complement component and its antibodies reflect disease activity of lupus nephritis.
Serum levels and renal deposition of C1q complement component and its antibodies reflect disease activity of lupus nephritis.
复制标题
C1q补体成分及其抗体的血清水平和肾脏沉积反映狼疮性肾炎的疾病活动性
DOI：
10.1186/1471-2369-14-63
复制
发表时间：
2013-03-19
期刊：
影响因子：
2.3
通讯作者：
Zhao MH
中科院分区：
文献类型：
--
作者：
Tan Y;Song D;Wu LH;Yu F;Zhao MH
狼疮性肾炎被认为是SLE发病率和死亡率的主要原因。很少有研究关注人类狼疮性肾炎患者循环中抗C1q抗体与肾脏C1q沉积之间的关系。本研究检测了中国狼疮性肾炎患者血清C1q水平、循环中抗C1q抗体的存在、肾脏C1q沉积，并进一步分析其与临床和病理活动的关系。方法对218例有长期随访资料的狼疮性肾炎患者的血清和肾活检标本进行分析。检测血清中C1q和抗C1q自身抗体水平。结果狼疮性肾炎患者血清C1q水平显著低于正常对照组[33.81 ± 20.36vs.61.97 ± 10.50μg/ml(P<； 0.001)]。狼疮性肾炎患者抗C1q抗体阳性率为42.7%(93/218)，肾小球C1q沉积率为71.6%(156/218)，C1q血管沉积率为86.2%(188/218)。血清C1q水平和抗C1q抗体水平与SLEDAI评分(P<； 0.001，P= 0.012)、肾脏总活动性指数评分(P <；0.001，P<； 0.001)相关。免疫荧光显示C1q和Ig G颗粒阳性染色几乎完全分布在肾小球毛细血管壁和系膜区。抗C1q抗体阳性患者血清C1q水平显著低于无C1q抗体患者(23.82[0.6，69.62]μg/mlV.S.37.36[0.64，82.83]μg/ml，P<； 0.001)。抗C1q抗体与肾小球C1q沉积相关(P<； 0.001)，与肾血管C1q沉积无关(P= 0.203)。结论抗C1q自身抗体与血清C1q水平及肾小球C1q沉积密切相关。肾脏至少是抗C1q自身抗体的靶器官之一。
BackgroundLupus nephritis is considered to be a principal cause of morbidity and mortality in SLE. Few studies focus on the association between anti-C1q antibodies in circulation and renal C1q deposition in human lupus nephritis. In this study, we detected the serum levels of C1q, presence of anti-C1q antibodies in circulation, renal C1q deposition and further analyzed their associations with clinical and pathological activity in a large cohort of Chinese lupus nephritis patients.MethodsSera and renal biopsies from 218 consecutive patients with lupus nephritis with long-term follow up data were studied. Sera were tested for levels of C1q and anti-C1q autoantibodies. Associations of levels of C1q, anti-C1q autoantibodies with renal deposition of C1q, clinical and histopathological data and renal outcome were further investigated.ResultsThe levels of serum C1q were significantly lower in lupus nephritis than that in normal controls [33.81 ± 20.36 v.s. 61.97 ± 10.50 μg/ml (P< 0.001)]. The prevalence of anti-C1q antibodies, ratios of glomerular and vascular deposition of C1q in patients with lupus nephritis were 42.7% (93/218), 71.6% (156/218) and 86.2% (188/218), respectively. The serum C1q levels and anti-C1q antibodies were associated with SLEDAI scores (P< 0.001, P= 0.012, respectively), renal total activity indices scores (P <0.001,P< 0.001, respectively). Granular positive staining of C1q and IgG by immunofluorescence was co-localized almost completely along the glomerular capillary wall and mesangial areas. Patients with anti-C1q antibodies presented with significantly lower serum C1q levels than those without it (23.82 [0.60, 69.62] μg/ml v.s. 37.36 [0.64, 82.83] μg/ml,P< 0.001). The presence of anti-C1q antibodies was associated with the presence of glomerular C1q deposition (P< 0.001), but not with the presence of renal vascular C1q deposition (P= 0.203).ConclusionAnti-C1q autoantibodies were closely associated with serum levels of C1q and glomerular deposition of C1q. Kidney is at least one of the target organs of anti-C1q autoantibodies.
登录
查看更多内容
影响因子：
3.7
作者：
Nascimento EJ;Silva AM;Cordeiro MT;Brito CA;Gil LH;Braga-Neto U;Marques ET
通讯作者：
Marques ET
影响因子：
6.1
作者：
Fang, Qi-Ying;Yu, Feng;Zhao, Ming-hui
通讯作者：
Zhao, Ming-hui
影响因子：
--
作者：
Katsumata, Yasuhiro;Miyake, Kohei;Yamanaka, Hisashi
通讯作者：
Yamanaka, Hisashi
影响因子：
4.9
作者：
Sjöwall C;Zickert A;Skogh T;Wetterö J;Gunnarsson I
通讯作者：
Gunnarsson I
影响因子：
1.6
作者：
Cervera, R;Khamashta, MA;Hughes, GRV
通讯作者：
Hughes, GRV