Intravenous azithromycin-induced ototoxicity
Intravenous azithromycin-induced ototoxicity
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DOI：
10.1592/phco.19.3.245.30930
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发表时间：
1999-02-01
期刊：
影响因子：
4.1
通讯作者：
Dresing, JM
中科院分区：
文献类型：
--
作者：
Bizjak, ED;Haug, MT;Dresing, JM
静脉阿奇霉素越来越多地用于治疗社区获得性肺炎住院患者。大环内酯类抗生素会引起耳毒性，这种情况在达到高血清浓度时最常发生。目前静脉注射阿奇霉素的剂量指南可能导致比口服阿奇霉素高得多的血清浓度。我们描述了一位 47 岁的女性，她在静脉注射阿奇霉素 8 天后出现完全耳聋。
Intravenous azithromycin is increasingly administered for treatment of hospitalized patients with community-acquired pneumonia. Macrolide antibiotics cause ototoxicity, which occurs most frequently when high serum concentrations are achieved. Current dosing guidelines for intravenous azithromycin can result in much higher serum concentrations than is seen with oral administration. We describe a 47-year-old woman who developed complete deafness after receiving 8 days of intravenous azithromycin.