Cancer Cell Membrane-Coated Gold Nanocages with Hyperthermia-Triggered Drug Release and Homotypic Target Inhibit Growth and Metastasis of Breast Cancer
Cancer Cell Membrane-Coated Gold Nanocages with Hyperthermia-Triggered Drug Release and Homotypic Target Inhibit Growth and Metastasis of Breast Cancer
复制标题
具有热触发药物释放和同型靶标的癌细胞膜包被的金纳米笼抑制乳腺癌的生长和转移
DOI：
10.1002/adfm.201604300
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发表时间：
2017-01-01
影响因子：
19
通讯作者：
Li, Yaping
中科院分区：
文献类型：
--
作者：
Sun, Huiping;Su, Jinghan;Li, Yaping
细胞特异性靶向药物递送和癌细胞的药物控制释放仍然是抗乳腺癌转移治疗的主要挑战。在此，作者首次报道了一种仿生药物递送系统，该系统由负载阿霉素（DOX）的金纳米笼（AuNs）作为内核和4T1癌细胞膜（CMV）作为外壳（掺入DOX的AuNs（CDAuNs）的涂层表面）组成。 CDAuNs完美地利用具有同型靶向和热响应能力的天然癌细胞膜来覆盖具有光热特性的DAuNs，可以实现同型肿瘤细胞的选择性靶向、近红外激光照射下的热触发药物释放以及化疗/光热治疗的结合。 CDAuN 在高温下表现出 DOX 的刺激释放，并且在体外对 4T1 细胞具有高细胞特异性靶向性。此外，在4T1原位乳腺肿瘤模型中观察到了优异的联合治疗，肿瘤体积和转移结节的抑制率分别为98.9%和98.5%。因此，CDAuN 可能成为未来乳腺癌治疗的一种有前途的纳米递送系统。
The cell-specific targeting drug delivery and controlled release of drug at the cancer cells are still the main challenges for anti-breast cancer metastasis therapy. Herein, the authors first report a biomimetic drug delivery system composed of doxorubicin (DOX)-loaded gold nanocages (AuNs) as the inner cores and 4T1 cancer cell membranes (CMVs) as the outer shells (coated surface of DOX-incorporated AuNs (CDAuNs)). The CDAuNs, perfectly utilizing the natural cancer cell membranes with the homotypic targeting and hyperthermia-responsive ability to cap the DAuNs with the photothermal property, can realize the selective targeting of the homotypic tumor cells, hyperthermia-triggered drug release under the near-infrared laser irradiation, and the combination of chemo/photothermal therapy. The CDAuNs exhibit a stimuli-release of DOX under the hyperthermia and a high cell-specific targeting of the 4T1 cells in vitro. Moreover, the excellent combinational therapy with about 98.9% and 98.5% inhibiting rates of the tumor volume and metastatic nodules is observed in the 4T1 orthotopic mammary tumor models. As a result, CDAuNs can be a promising nanodelivery system for the future therapy of breast cancer.