Estimating tissue iron burden: current status and future prospects.
Estimating tissue iron burden: current status and future prospects.
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DOI：
10.1111/bjh.13374
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发表时间：
2015-07
影响因子：
6.5
通讯作者：
Wood JC
中科院分区：
文献类型：
--
作者：
Wood JC
随着血红蛋白病患者获得更多良好的医疗护理，以及骨髓增生异常综合征的治疗方法的改善，铁超载正在成为一个日益严重的问题。铁螯合疗法的治疗选择增加了，许多患者现在接受联合疗法。然而，铁螯合疗法的最佳利用不仅需要了解全身铁负荷，还需要了解不同器官之间的相对铁分配。介绍了肝外铁沉积的生理基础，以帮助识别心脏和内分泌并发症风险最高的患者。这份手稿回顾了监测全球铁超载状态的最新技术水平以及它的划分。讨论了血浆标记物、计算机断层扫描、肝脏活检、磁感应装置和磁共振成像(MRI)技术，但MRI已成为临床应用的主导。讨论了近期胰腺和垂体MRI研究对临床实践的潜在影响以及其他正在进行的工作。临床方案是从血红蛋白疾病的经验中获得的，但可能为其他铁超载疾病提供有用的指导原则，如骨髓增生异常综合征。
Iron overload is becoming an increasing problem as haemoglobinopathy patients gain greater access to good medical care and as therapies for myelodysplastic syndromes improve. Therapeutic options for iron chelation therapy have increased and many patients now receive combination therapies. However, optimal utilization of iron chelation therapy requires knowledge not only of the total body iron burden but the relative iron distribution among the different organs. The physiological basis for extrahepatic iron deposition is presented in order to help identify patients at highest risk for cardiac and endocrine complications. This manuscript reviews the current state of the art for monitoring global iron overload status as well as its compartmentalization. Plasma markers, computerized tomography, liver biopsy, magnetic susceptibility devices and magnetic resonance imaging (MRI) techniques are all discussed but MRI has come to dominate clinical practice. The potential impact of recent pancreatic and pituitary MRI studies on clinical practice are discussed as well as other works-in-progress. Clinical protocols are derived from experience in haemoglobinopathies but may provide useful guiding principles for other iron overload disorders, such as myelodysplastic syndromes.
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影响因子：
3
作者：
Evans, Robert W.;Rafique, Roozina;Hider, Robert C.
通讯作者：
Hider, Robert C.
影响因子：
37.8
作者：
Carpenter JP;He T;Kirk P;Roughton M;Anderson LJ;de Noronha SV;Sheppard MN;Porter JB;Walker JM;Wood JC;Galanello R;Forni G;Catani G;Matta G;Fucharoen S;Fleming A;House MJ;Black G;Firmin DN;St Pierre TG;Pennell DJ
通讯作者：
Pennell DJ
影响因子：
2.6
作者：
Brewer, Casey;Otto-Duessel, Maya;Wood, John C.
通讯作者：
Wood, John C.
影响因子：
12.8
作者：
BRITTENHAM, GM;COHEN, AR;HARRIS, JW
通讯作者：
HARRIS, JW
影响因子：
12.6
作者：
Barton, James C.;Barton, J. Clayborn;Adams, Paul C.
通讯作者：
Adams, Paul C.