The BAR Domain Superfamily Proteins from Subcellular Structures to Human Diseases.
The BAR Domain Superfamily Proteins from Subcellular Structures to Human Diseases.
复制标题
DOI：
10.3390/membranes2010091
复制
发表时间：
2012-02-27
期刊：
影响因子：
4.2
通讯作者：
Suetsugu S
中科院分区：
文献类型：
--
作者：
Safari F;Suetsugu S
真核细胞具有复杂的膜系统。最外层的质膜包含各种亚结构，如内陷和突起，参与内吞和细胞迁移。此外，细胞内的膜间隔，如自噬小体和内噬小体，是细胞生存所必需的。Bin-AmphiPhyin-Rvs167(Bar)结构域超家族蛋白通过其结构决定的膜结合表面在膜重塑中发挥重要作用。BAR结构域超家族蛋白种类繁多，每个家族成员似乎都参与了某些亚细胞结构或细胞内膜隔间的形成。大多数BAR结构域超家族蛋白都含有SH3结构域，它与膜断裂分子Dynamin、肌动蛋白调节蛋白WASP/WAVE以及几个信号转导分子结合，为膜与细胞骨架或其他机制之间提供可能的联系。本文就含SH3结构域的BAR超家族蛋白(S)的研究现状进行综述。并对BAR结构域超家族蛋白在多种疾病中的作用进行了讨论。
Eukaryotic cells have complicated membrane systems. The outermost plasma membrane contains various substructures, such as invaginations and protrusions, which are involved in endocytosis and cell migration. Moreover, the intracellular membrane compartments, such as autophagosomes and endosomes, are essential for cellular viability. The Bin-Amphiphysin-Rvs167 (BAR) domain superfamily proteins are important players in membrane remodeling through their structurally determined membrane binding surfaces. A variety of BAR domain superfamily proteins exist, and each family member appears to be involved in the formation of certain subcellular structures or intracellular membrane compartments. Most of the BAR domain superfamily proteins contain SH3 domains, which bind to the membrane scission molecule, dynamin, as well as the actin regulatory WASP/WAVE proteins and several signal transduction molecules, providing possible links between the membrane and the cytoskeleton or other machineries. In this review, we summarize the current information about each BAR superfamily protein with an SH3 domain(s). The involvement of BAR domain superfamily proteins in various diseases is also discussed.