USE OF CATHETER-TIP VELOCITY-PRESSURE TRANSDUCER TO EVALUATE LEFT-VENTRICULAR FUNCTION IN MAN - EFFECTS OF INTRAVENOUS PROPRANOLOL
USE OF CATHETER-TIP VELOCITY-PRESSURE TRANSDUCER TO EVALUATE LEFT-VENTRICULAR FUNCTION IN MAN - EFFECTS OF INTRAVENOUS PROPRANOLOL
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DOI：
10.1161/01.cir.61.5.946
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发表时间：
1980-01-01
期刊：
影响因子：
37.8
通讯作者：
CONTI, CR
中科院分区：
文献类型：
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作者：
KLINKE, WP;CHRISTIE, LG;CONTI, CR
使用带有2个高保真压力计的导管尖端速度传感器来评价静脉注射普萘洛尔（10 mg）对左心室（LV）血流动力学的影响。研究了9例无心力衰竭临床证据的患者。给药期间连续测量搏动性升主动脉血流速度和压力以及LV压力。测定每搏输出量指数、每搏作功指数、LV舒张末期压、最大血流速度和加速度以及最大LV dP/dt [舒张末期压的一阶导数]的逐搏变化。普萘洛尔使最大血流速度降低（从58 ± 0.01）。4.7至42 .+-。5.1 cm/s，P < 0.002）加速度（从1181 . ±. 130到847 .+-. 117 cm/s2，P < 0.002），最大dP/dt（从1361 . ±. 70到1146 .+-. 63 mm Hg/s，P < 0.002），每搏输出量指数（从47 . ±. 3.0至38 .+-。3.2 ml/m2，P < 0.002）和总每搏作功指数（从702 . ±. 33到603 .+-. 44 mJ/m2，P < 0.04），平均主动脉压、收缩压峰值和左室舒张末压变化不大。在开始普萘洛尔治疗后1分钟内可检测到心肌功能的抑制，并且在心房起搏消除负性变时作用后持续存在。多传感器导管技术可以快速和安全地检测心血管功能的变化，在普萘洛尔管理清醒的人。
A catheter-tip velocity transducer with 2 high-fidelity pressure manometers was used to evaluate the left ventricular (LV) hemodynamic effects of i.v. propranolol (10 mg). Nine patients without clinical evidence of heart failure were studied. Pulsatile ascending aortic blood flow velocity and pressure and LV pressure were measured continuously during drug administration. Beat-to-beat changes in stroke volume index, stroke work index, LV end-diastolic pressure, maximum blood flow velocity and acceleration and maximum LV dP/dt [1st derivative of end diastole pressure] were determined. Propranolol produced a decrease in maximum blood flow velocity (from 58 .+-. 4.7 to 42 .+-. 5.1 cm/s, P < 0.002) acceleration (from 1181 .+-. 130 to 847 .+-. 117 cm/s2, P < 0.002), max dP/dt (from 1361 .+-. 70 to 1146 .+-. 63 mm Hg/s, P < 0.002), stroke volume index (from 47 .+-. 3.0 to 38 .+-. 3.2 ml/m2, P < 0.002) and total stroke work index (from 702 .+-. 33 to 603 .+-. 44 mJ/m2, P < 0.04) with little change in mean aortic pressure, peak systolic pressure and LV end-diastolic pressure. Depression in myocardial function was detectable within 1 min after initiation of propranolol and persisted when negative chronotropic effects were eliminated by atrial pacing. The multisensor catheter technique allows rapid and safe detection of changes in cardiovascular function during propranolol administration in conscious man.