The Intestinal Cinnamaldehyde Release and Antioxidative Capacity of Broiler Chickens Fed Diets Supplemented with Coated Oleum Cinnamomi
The Intestinal Cinnamaldehyde Release and Antioxidative Capacity of Broiler Chickens Fed Diets Supplemented with Coated Oleum Cinnamomi
复制标题
DOI：
10.3382/japr/pfz068
复制
发表时间：
2019-12
期刊：
影响因子：
--
通讯作者：
Qiang Cheng;Yi Xia;D. Yi;Yongqing Hou;Rui Duan;Shuangshuang Guo;B. Ding
中科院分区：
文献类型：
--
作者：
Qiang Cheng;Yi Xia;D. Yi;Yongqing Hou;Rui Duan;Shuangshuang Guo;B. Ding
肉桂油（OCM，肉桂油）是由芳香的肉桂植物生产的，越来越多地被用作动物饲料添加剂。OCM是一种富含多酚类化合物的天然产物，具有很强的抗氧化性。然而，由于OCM的高疏水性、挥发性、气味、分解快、在动物下胃肠道的利用率差等理化因素的限制，在饲料中直接添加OCM是值得怀疑的。因此，涂层OCM （cOCM）是解决这些问题的途径之一。本研究表明，饲粮中添加cOCM并不能提高肉仔鸡的生长性能，但对其免疫力和肠道完整性有有益影响。在本研究中，我们进一步研究了添加com的饲粮对鸡肠道肉桂醛释放和抗氧化能力的影响。由于肉桂醛是OCM的主要成分，我们通过测定鸟类小肠和盲肠食糜中肉桂醛的含量来评估cOCM在肠道中的释放。下肠OCM利用率的增加为发挥其抗氧化作用提供了基础。饲粮中添加comm可提高血浆和肠黏膜中抗氧化酶活性，降低超氧化物水平。提高抗氧化能力是通过调节核因子红系2相关因子2及下游抗氧化酶的基因表达来实现的。
SUMMARY Oleum cinnamomi (OCM, cinnamon oil), which is produced by aromatic cinnamon plants, is increasingly used as a feed additive to animal diets. OCM is a natural product rich in polyphenolic compounds that exhibit strong antioxidative property. However, the direct addition of OCM to the feed is questionable due to several limiting physical–chemical factors such as the high hydrophobicity, volatility, odor, fast decomposition, and poor availability in the lower gastrointestinal tract of animals. Therefore, the coated form of OCM (cOCM) is one of the ways to solve these concerns. We have demonstrated that dietary cOCM supplementation did not improve the growth performance of broiler chickens, but it showed beneficial effects on immunity and intestinal integrity. In the current study, we further investigated the intestinal cinnamaldehyde release and antioxidative capacity of chickens fed cOCM-supplemented diets. As cinnamaldehyde is a major constituent of OCM, we evaluated the release of cOCM in the intestine of birds by determining the contents of cinnamaldehyde in the digesta of small intestine and cecum. The increased availability of OCM in the lower intestine supplied a foundation for exerting its antioxidative effects. The activities of antioxidative enzymes were increased and superoxide levels were decreased in the plasma and intestinal mucosa of birds fed cOCM-supplemented diets. The improvement of antioxidative capacity was achieved by modulating the gene expression of nuclear factor erythroid 2-related factor 2 and downstream antioxidative enzymes.