Short-term practice effects in amnestic mild cognitive impairment: implications for diagnosis and treatment
Short-term practice effects in amnestic mild cognitive impairment: implications for diagnosis and treatment
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DOI：
10.1017/s1041610208007254
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发表时间：
2008-10-01
影响因子：
7
通讯作者：
Paulsen, Jane S.
中科院分区：
文献类型：
--
作者：
Duff, Kevin;Beglinger, Leigh J.;Paulsen, Jane S.
背景：在健康的老年人中，练习效应已被广泛报道，但由于重复接触测试材料而产生的这些改善在轻度认知障碍（MCI）患者中则更不明确。
方法：本研究通过对59名遗忘型MCI老年人和62名认知完好的老年人在一周内重复进行一组简短的认知测试，检验了MCI患者的短期练习效应。
结果：与认知完好的同龄人相比，遗忘型MCI患者在两项延迟回忆指标上有显著更大的改善（p < 0.01）。这两组之间所有其他练习效应相当。练习效应显著提高了MCI组的分数，以至于一周后其中49%被重新归类为“认知完好”，而另外51%仍保持为MCI“稳定状态”。二次分析表明，MCI - 认知完好组在两项记忆指标上比其同龄人表现出更大的练习效应（p < 0.01）。
结论：这些结果继续让我们了解MCI中记忆缺陷的性质，并可能对这种遗忘病症的诊断和可能的治疗产生影响。
Background: Practice effects have been widely reported in healthy older adults, but these improvements due to repeat exposure to test materials have been more equivocal in individuals with mild cognitive impairment (MCI).Methods: The current study examined short-term practice effects in MCI by repeating a brief battery of cognitive tests across one week in 59 older adults with amnestic MCI and 62 intact older adults.Results: Participants with amnestic MCI showed significantly greater improvements on two delayed recall measures (p < 0.01) compared to intact peers. All other practice effects were comparable between these two groups. Practice effects significantly improved scores in the MCI group so that 49% of them were reclassified as "intact" after one week, whereas the other 51% remained "stable" as MCI. Secondary analyses indicated the MCI-Intact group demonstrated larger practice effects on two memory measures than their peers (p < 0.01).Conclusions: These results continue to inform us about the nature of memory deficits in MCI, and could have implications for the diagnosis and possible treatment of this amnestic condition.