Microbubbles induce renal hemorrhage when exposed to diagnostic ultrasound in anesthetized rats
Microbubbles induce renal hemorrhage when exposed to diagnostic ultrasound in anesthetized rats
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DOI：
10.1016/s0301-5629(02)00651-8
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发表时间：
2002-11-01
影响因子：
2.9
通讯作者：
Brandenburger, GH
中科院分区：
文献类型：
--
作者：
Wible, JH;Galen, KP;Brandenburger, GH
使用临床成像系统产生超声（US）生物效应存在争议。我们测试的假设，即微泡的存在下，在美国领域的医疗成像仪诱导生物效应。在施用微泡后，使用医学成像系统对麻醉大鼠的两个肾脏进行声穿透5分钟。使用连续模式（30 Hz）对一个肾脏进行声穿透，使用间歇（1 Hz）技术对另一个肾脏进行声穿透。将微泡暴露于三种不同的换能器频率和四种换能器输出功率。超声处理后，将动物安乐死，取出肾脏，并在“盲法”条件下使用规定的量表对其大体外观进行评分。在给予微泡后，肾脏的US成像引起肾组织出血。出血的严重程度和面积随着换能器功率的增加和换能器频率的降低而增加。微泡存在下的间歇性声照射比连续成像技术产生更大程度的肾出血。（电子邮件：james. tycohealthcare.com）（C）2002年世界医学生物学超声联合会。
The generation of ultrasound (US) bioeffects using a clinical imaging system is controversial. We tested the hypothesis that the presence of microbubbles in the US field of a medical imager induces biologic effects. Both kidneys of anesthetized rats were insonified for 5 min using a medical imaging system after the administration of microbubbles. One kidney was insonified using a continuous mode (30 Hz) and the opposite kidney was insonified using an intermittent (1 Hz) technique. The microbubbles were exposed to three different transducer frequencies and four transducer output powers. After insonification, the animals were euthanized, the kidneys were removed and their gross appearance scored under "blinded" conditions using a defined scale. After the administration of microbubbles, US imaging of the kidney caused hemorrhage in the renal tissue. The severity and area of hemorrhage increased with an increase in the transducer power and a decrease in the transducer frequency. Intermittent insonification in the presence of microbubbles produced a greater degree of renal hemorrhage than continuous imaging techniques. (E-mail: james.wible@tycohealthcare.com) (C) 2002 World Federation for Ultrasound in Medicine Biology.