A functional comparison of animal anterior cruciate ligament models to the human anterior cruciate ligament
A functional comparison of animal anterior cruciate ligament models to the human anterior cruciate ligament
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DOI：
10.1114/1.91
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发表时间：
1998-05-01
影响因子：
3.8
通讯作者：
Woo, SLY
中科院分区：
文献类型：
--
作者：
Xerogeanes, JW;Fox, RJ;Woo, SLY
许多研究者使用动物模型来阐明人类前交叉韧带（ACL）的作用。由于这些模型在解剖学和生物力学上都与人类前交叉韧带不相同，因此有必要对这些模型进行客观比较。为此，我们使用了通用力力矩传感器来测量和比较前交叉韧带和人、猪、山羊和绵羊膝盖的前内侧（AM）和后外侧（PL）束的原位力，包括大小和方向。在膝关节屈曲90度时，使用Instron施加50和100 N的胫骨前负荷，同时使用通用力力矩传感器测量前交叉韧带对胫骨施加的力，即前交叉韧带的原位力。我们发现山羊和绵羊前交叉韧带、AM和PL束与人类前交叉韧带、AM和PL束所承受的力的大小有显著差异。山羊和绵羊的前交叉韧带和AM束的原位力方向也与人类不同。猪膝与人的不同之处在于，在胫骨前负荷作用下，左胫束的原位力的大小和方向不同。动物模型与人类膝关节之间的显著差异表明，山羊和绵羊膝关节在模拟人类前交叉韧带方面可能存在局限性，而猪膝关节可能是实验研究的首选模型。(C) 1998生物医学工程学会。
Many investigators have used animal models to clarify the role of the human anterior cruciate ligament (ACL). Because none of these models are anatomically and biomechanically identical to the human ACL, there exists a need for an objective comparison of these models. To do this, we used a universal force-moment sensor to measure and compare the in situ forces, including magnitude and direction, of the ACL and the anteromedial (AM) and posterolateral (PL) bundles of human, pig, goat, and sheep knees. An Instron was used to apply 50 and 100 N anterior tibial loads at 90 degrees of knee flexion, while a universal force-moment sensor was used to measure the forces applied by the ACL to the tibia, the in situ force of the ACL. We found significant differences between the magnitude of force experienced by the goat and sheep ACL and AM and PL bundles when compared with the human ACL and AM and PL bundles. Also, the direction of the in situ force in the ACL and AM bundles of the goat and sheep were different from the human. The pig knee differed from the human only in the magnitude and direction of the in situ force in the PL bundle in response under anterior tibial loading. A tally of the significant differences between the animal models and the human knees indicates that goat and sheep knees may have limitations in modeling the human ACL, while the pig knee may be the preferred model for experimental studies. (C) 1998 Biomedical Engineering Society.