WATERFALL SEQUENCE FOR INTRINSIC BLOOD CLOTTING
WATERFALL SEQUENCE FOR INTRINSIC BLOOD CLOTTING
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DOI：
10.1126/science.145.3638.1310
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发表时间：
1964-01-01
期刊：
影响因子：
56.9
通讯作者：
RATNOFF, OD
中科院分区：
文献类型：
--
作者：
DAVIE, EW;RATNOFF, OD
提出了一个简单的瀑布式序列来解释在纤维蛋白凝块形成过程中各种蛋白质凝血因子的作用。当凝血启动时，除纤维蛋白原外的每个凝血因子都转化为具有酶活性的形式。这种激活以逐步的顺序发生，每个新形成的酶与其特定底物反应，将其转化为一种活性酶。
A simple waterfall sequence is proposed to explain the function of the various protein clotting factors during the formation of the fibrin clot. When clotting is initiated, each clotting factor except fibrinogen is converted to a form that has enzymatic activity. This activation occurs in a stepwise sequence with each newly formed enzyme reacting with its specific substrate, converting it to an active enzyme.