Dose-Dependent Neurologic Abnormalities in Workers Exposed to 1-Bromopropane
Dose-Dependent Neurologic Abnormalities in Workers Exposed to 1-Bromopropane
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DOI：
10.1097/jom.0b013e3181eaded7
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发表时间：
2010-07
影响因子：
3.2
通讯作者：
Wei-hua Li;E. Shibata;Zhijun Zhou;S. Ichihara;Hailan Wang;Qiang-yi Wang;Jiefei Li;Lingyi Zhang;K. Wakai;Y. Takeuchi;Xun-cheng Ding;G. Ichihara
中科院分区：
文献类型：
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作者：
Wei-hua Li;E. Shibata;Zhijun Zhou;S. Ichihara;Hailan Wang;Qiang-yi Wang;Jiefei Li;Lingyi Zhang;K. Wakai;Y. Takeuchi;Xun-cheng Ding;G. Ichihara
目的：调查中国 1-BP 生产工厂中 1-溴丙烷 (1-BP) 的健康影响及其剂量依赖性。方法：对三个 1-BP 工厂的 60 名女性和 26 名男性工人以及相同数量的年龄、性别和地区匹配的对照进行访谈和检查。估计了个体工人的时间加权平均暴露水平。结果：暴露水平回归分析显示，女工胫神经远端潜伏期、脚趾震动感阈值、乳酸脱氢酶、促甲状腺激素和卵泡刺激素呈剂量依赖性增加。分析还显示，女性工人的腓肠神经感觉神经传导速度、红细胞和血细胞比容呈剂量依赖性下降。结论：结果表明，女工接触 1-BP 会引起剂量依赖性神经毒性。
Objectives: To investigate the health effects of 1-bromopropane (1-BP) and its dose-dependency in 1-BP production factories in China. Methods: Data of 60 female and 26 male workers in three 1-BP factories and the same number of age-, sex-, and region-matched controls were interviewed and examined. The time-weighed average exposure levels of individual workers were estimated. Results: Regression analysis on exposure level showed dose-dependent increase in the distal latency of tibial nerve, threshold for vibration sense in toes, lactate dehydrogenase, thyroid stimulating hormone, and follicle stimulating hormone in female workers. The analysis also showed dose-dependent decrease in sensory nerve conduction velocity of the sural nerve, red blood cell, and hematocrit in female workers. Conclusions: The results indicate that exposure to 1-BP induces dose-dependent neurotoxicity in female workers.