Association of physical activity with reproductive hormones: the Penn Ovarian Aging Study.
Association of physical activity with reproductive hormones: the Penn Ovarian Aging Study.
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体力活动与生殖激素的关联：宾夕法尼亚大学卵巢衰老研究。
DOI：
10.1158/1055-9965.epi-07-0061
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发表时间：
2007
期刊：
影响因子：
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通讯作者：
Freeman,EllenW
中科院分区：
文献类型：
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作者：
Schmitz,KathrynH;Lin,Hui;Sammel,MaryD;Gracia,ClarissaR;Nelson,DeborahB;Kapoor,Shiv;DeBlasis,TraceyL;Freeman,EllenW
背景：体力活动可能通过减少循环生殖激素（雌激素和雄激素）来降低患乳腺癌的风险。体力活动也可能在调节更年期症状方面发挥作用。很少有研究探讨体力活动与激素水平的关系。没有人研究过更年期过渡对体力活动和生殖激素水平之间关联的潜在影响。材料和方法：来自宾夕法尼亚大学卵巢衰老研究的数据用于该分析。 391 名女性在 10 年内对自我报告的身体活动进行了四次评估，并持续到更年期过渡期。其他评估包括通过 RIA 进行的生殖激素（雌二醇、黄体生成素、卵泡刺激素、睾酮、硫酸脱氢表雄酮）、体重和身高。开发了多变量重复测量回归模型来比较体力活动三分位内的生殖激素水平，调整年龄、随访时间、吸烟和种族。结果：在过渡阶段后期的亚组中，活动水平与雌二醇呈负相关。雌二醇的调整平均值为 24.6 和 37.9，当比较最高和最低活性三分位时，雌二醇的相对差异为 54%（P=0.02）。同样，在这个亚组中，体力活动和睾酮水平之间存在负相关（最高和最低三分位数的平均值为 11.1 和 15.94，相对差异为 47%；P= 0.01）。活动与任何其他生殖激素没有显着关联。结论：这些结果确定了更年期过渡的一个特定窗口，在此期间体力活动与雌二醇和/或睾酮水平降低相关。 （癌症流行病学生物标志物，2007 年以前；16(10):2042–7）
Background: Physical activity is associated with reduced risk for breast cancer, perhaps through reductions in circulating reproductive hormones (estrogens and androgens). There may also be a role for physical activity in regulating menopausal symptoms. Few studies have examined associations of physical activity on hormone levels. None have examined the potential effect of the menopausal transition on the associations between physical activity and reproductive hormone levels.Materials and Methods: Data from the Penn Ovarian Aging Study were used for this analysis. Self-reported physical activity was assessed in 391 women up to four times over 10 years and extending across the menopausal transition. Other assessments included reproductive hormones via RIA (estradiol, luteinizing hormone, follicle-stimulating hormone, testosterone, DHEA sulfate), body weight, and height. Multivariate repeated measures regression models were developed to compare reproductive hormone levels within physical activity tertiles, adjusting for age, follow-up time, smoking, and ethnicity.Results: Activity level was inversely associated with estradiol in the subgroup in the late transition stage. Adjusted means for estradiol were 24.6 and 37.9, a relative difference of 54% in estradiol when comparing highest to lowest activity tertile (P= 0.02). Similarly, in this subgroup, there was an inverse association between physical activity and testosterone levels (means of 11.1 and 15.94 in the highest and lowest tertile, a 47% relative difference;P= 0.01). There were no significant associations of activity with any other reproductive hormone.Conclusions: These results identify a particular window of the menopausal transition during which physical activity is associated with reduced estradiol and/or testosterone levels. (Cancer Epidemiol Biomarkers Prev 2007;16(10):2042–7)