TETRACYCLINES INHIBIT TISSUE COLLAGENASE ACTIVITY - A NEW MECHANISM IN THE TREATMENT OF PERIODONTAL-DISEASE
TETRACYCLINES INHIBIT TISSUE COLLAGENASE ACTIVITY - A NEW MECHANISM IN THE TREATMENT OF PERIODONTAL-DISEASE
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DOI：
10.1111/j.1600-0765.1984.tb01334.x
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发表时间：
1984-01-01
影响因子：
3.5
通讯作者：
PERRY, H
中科院分区：
文献类型：
--
作者：
GOLUB, LM;RAMAMURTHY, N;PERRY, H
许多研究人员已经探索了系统给药或局部应用四环素作为辅助治疗人类和实验动物牙周病的方法（Ciancio, Mather & McMullen 1980）。Williams et al. 1981, Kornman & Karl 1982, Slots & Rosling 1983。Lindhe, LiJjenberg & Adielason 1983。1984年，哈桑和阿迪。古德森。Hogan & Dunham 1984)。在所有这些研究中，抗生素家族的有效性仅仅归因于它们对牙龈下牙周病微生物的抑制。在最近的一项研究中，二甲胺四环素（一种半合成四环素）被发现具有一种新的、可能用于血液治疗的特性：能够直接抑制胶原溶解酶的活性，包括但不一定限于哺乳动物胶原酶（Golub et al. 1983）。作者认为，四环素的这一特性在临床上可用于治疗以胶原蛋白分解为特征的疾病。
A nutnber of investigators have explored the use of systemically-administered or locallyapplied tetracyclines as adjuncts in the treatment of periodontal diseases both in humans and experimental animals (Ciancio, Mather & McMullen 1980. Williams et al. 1981, Kornman & Karl 1982, Slots & Rosling 1983. Lindhe, LiJjenberg & Adielason 1983. Hassan & Addy 1984. Goodson. Hogan & Dunham 1984). In all such studies, the etTicacy of this family of antibiotics was attributed solely to their suppression of subgingival periodontopathie microorganisms. In a recent investigation, minocychne (a semi-synthetic tetracycline) was found to possess a new, potentially ehemotherapeutically useful property: the ability to directly inhibit the activity of collagenolytic enzymes including, but not necessarily limited to, mammalian collagenase (Golub et al. 1983). The authors proposed that this property of tetracyclines could be clinically useful in treatitig diseases characterized by collagen breakdown.