NEURITIC PLAQUE AMYLOID IN ALZHEIMERS-DISEASE IS HIGHLY RACEMIZED
NEURITIC PLAQUE AMYLOID IN ALZHEIMERS-DISEASE IS HIGHLY RACEMIZED
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DOI：
10.1111/j.1471-4159.1988.tb13231.x
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发表时间：
1988-01-01
影响因子：
4.7
通讯作者：
MIRRA, SS
中科院分区：
文献类型：
--
作者：
SHAPIRA, R;AUSTIN, GE;MIRRA, SS
研究了阿尔茨海默病脑组织中神经炎斑核心淀粉样蛋白的氨基酸外消旋化程度。长寿的人类蛋白质在人的一生中表现出某些氨基酸的外消旋化。发现纯化的核心淀粉样蛋白含有相对较大比例的D-天冬氨酸和D-丝氨酸，表明神经炎斑块淀粉样蛋白来源于长寿命的前体蛋白。或者，蛋白质氨基酸的外消旋化可能在阿尔茨海默病中异常加速。
Neuritic plaque core amyloid protein in Alzheimer''s disease brain tissue was investigated for the extent of amino acid racemization. Long-lived human proteins exhibit racemization of certain amino acids over the course of a human lifetime. Purified core amyloid was found to contain relatively large proportions of D-aspartate and D-serine, suggesting that neuritic plaque amyloid is derived from a long-lived precursor protein. Alternatively, racemization of protein amino acids may be abnormally accelerated in Alzheimer''s disease.