The relationship of insulin resistance estimated by triglyceride glucose index and coronary plaque characteristics.
The relationship of insulin resistance estimated by triglyceride glucose index and coronary plaque characteristics.
复制标题
胰岛素抵抗通过甘油三酸酯葡萄糖指数和冠状斑块特征估计的关系。
DOI：
10.1097/md.0000000000010726
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发表时间：
2018-05
期刊：
影响因子：
1.6
通讯作者：
Chang HJ
中科院分区：
文献类型：
--
作者：
Won KB;Kim YS;Lee BK;Heo R;Han D;Lee JH;Lee SE;Sung JM;Cho I;Park HB;Cho IJ;Chang HJ
甘油三酯葡萄糖（TyG）指数是一个有用的替代指标，胰岛素抵抗，这是一个重要的危险因素，冠状动脉疾病（CAD）。然而，关于TyG指数和冠状动脉斑块特征的关系的数据有限。这项研究包括2840名肾功能接近正常的参与者，他们接受了冠状动脉计算机断层扫描血管造影术。CAD定义为存在任何斑块，阻塞性CAD定义为存在≥50%狭窄的斑块。评价TyG指数与非钙化斑块（NCP）、钙化或混合斑块（CMP）和冠状动脉钙化评分（CACS）之间的关系。根据TyG指数的四分位数将所有参与者分为4组。CAD和梗阻性CAD的患病率随四分位数的增加而显著增加。NCP和阻塞性NCP的风险在所有组中没有差异。然而，与I组（最低四分位数）相比，III组（比值比[OR]：1.438）和IV组（最高四分位数）（OR：1.895）发生CMP的风险较高（P <.05），II组（OR：1.469）、III组（OR：1.595）和IV组（OR：2.168）发生梗阻性CMP的风险较高（P <.05）。 多变量回归分析显示TyG指数与CAD（OR：1.700）、梗阻性CAD（OR：1.692）和CACS >400（OR：1.448）的风险增加相关（P <0.05）。 由于CMP风险增加，TyG指数与CAD的存在和严重程度独立相关。
The triglyceride glucose (TyG) index is a useful surrogate marker for insulin resistance, which is an important risk factor for coronary artery disease (CAD). However, data on the relationship of the TyG index and coronary plaque characteristics are limited. This study included 2840 participants with near-normal renal function who underwent coronary computed tomography angiography. CAD was defined as the presence of any plaques, and obstructive CAD was defined as the presence of plaques with ≥50% stenosis. The relationship between the TyG index and noncalcified plaque (NCP), calcified or mixed plaque (CMP), and coronary artery calcium score (CACS) was evaluated. All participants were stratified into 4 groups based on the quartiles of the TyG index. The prevalence of CAD and obstructive CAD significantly increased with increasing quartiles. The risk for NCP and obstructive NCP was not different among all groups. However, compared with group I (lowest quartile), the risk for CMP was higher in groups III (odds ratio [OR]: 1.438) and IV (highest quartile) (OR: 1.895) (P < .05), and that for obstructive CMP was higher in groups II (OR: 1.469), III (OR: 1.595), and IV (OR: 2.168) (P < .05). Multivariate regression analysis showed that the TyG index was associated with an increased risk for CAD (OR: 1.700), obstructive CAD (OR: 1.692), and CACS >400 (OR: 1.448) (P < .05). The TyG index was independently associated with the presence and severity of CAD due to an increased risk for CMP.