Prevalence and clinical characteristics of restless legs syndrome in Japanese patients with Parkinson's disease
Prevalence and clinical characteristics of restless legs syndrome in Japanese patients with Parkinson's disease
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DOI：
10.1002/mds.20734
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发表时间：
2006-03-01
影响因子：
8.6
通讯作者：
Nakashima, K
中科院分区：
文献类型：
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作者：
Nomura, T;Inoue, Y;Nakashima, K
为了探讨不宁腿综合征（RLS）在帕金森病（PD）中的临床意义及两者之间的因果关系，我们比较了165例PD患者与年龄和性别匹配的对照组（131例）的不宁腿综合征患病率和匹兹堡睡眠质量指数（PSQI）所反映的睡眠障碍严重程度。PD患者通过临床访谈诊断的RLS患病率明显高于对照组（12%对2.3%）。PD伴RLS患者的PSQI评分明显高于无RLS患者和对照组。而后两组的PSQI评分差异无统计学意义。PD合并RLS患者中，仅有2例有RLS家族史。只有3名PD患者要求治疗这种疾病。我们的研究结果强调了日本队列中RLS与PD之间的病因学联系，尽管RLS的严重程度较低，但RLS的存在被认为是加重PD患者睡眠障碍的最重要因素之一。(c) 2005年运动障碍协会。
To explore the clinical significance of restless legs syndrome (RLS) in Parkinson's disease (PD) and the causal relationship between these two disorders, we made a comparison of both the prevalence of RLS and the severity of sleep disturbance manifested on the Pittsburg Sleep Quality Index (PSQI) between patients with PD (n = 165) and age- and sex-matched control subjects (n = 131). The prevalence of RLS diagnosed by clinical interview was significantly higher in PD patients than in control Subjects (12% vs. 2.3%). PSQI score was significantly higher in PD patients with RLS than in both patients without RLS and controls. However, PSQI score was not statistically different between the latter two groups. Among the PD patients with RLS, only 2 had a positive family history of RLS. Only 3 PD patients had requested treatment for the disorder. Our results emphasize the etiological link between RLS and PD in a Japanese cohort, and the existence of RLS is thought to be one of the most important factors aggravating sleep disturbance in PD, despite the low RLS severity. (c) 2005 Movement Disorder Society.