Localization of the adenine nucleotide translocase gene ANT2 to chromosome Xq24-q25 with tight linkage to DXS425.
Localization of the adenine nucleotide translocase gene ANT2 to chromosome Xq24-q25 with tight linkage to DXS425.
复制标题
腺嘌呤核苷酸易位酶基因 ANT2 定位于染色体 Xq24-q25，与 DXS425 紧密连锁。
DOI：
10.1006/geno.1994.1675
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发表时间：
1994
期刊：
影响因子：
4.4
通讯作者：
Rappold,G
中科院分区：
文献类型：
--
作者：
Schiebel,K;Mertz,A;Winkelmann,M;Nagaraja,R;Rappold,G
腺苷二磷酸/三磷酸腺苷转位酶基因在真核细胞的能量代谢中起着关键作用，催化三磷酸腺苷和二磷酸腺苷跨线粒体膜的交换。它们是由三个高度保守的人类基因和至少九个假基因组成的基因家族的成员。它们都有显著的序列相似性，表明它们的进化起源于共同的祖先基因。ANT1与染色体7p上的标记连锁，ANT3定位于X染色体短臂上的伪常染色体区域(PAR)，位于端粒1.3Mb处，位于伪常染色体基因CSF2RA和113RA的近端，ANT2先前被定位在X染色体Xq的长臂上。在本研究中，我们利用含有人类X染色体不同部分的体细胞杂交来证实ANT2在X染色体长臂上的定位，并将其定位于Xq24-Q27。参考文献13，图1。
ADP/ATP translocase genes play a key role in the energy metabolism of the eukaryotic cell, catalyzing the exchange of ATP and ADP across the mitochondrial membrane. They are members of a gene family composed of three highly conserved human genes and at least nine pseudogenes. All share significant sequence similarity, suggesting their evolutionary origin from a common ancestral gene. ANT1 has been linked to markers on chromosome 7p, ANT3 maps to the pseudoautosomal region (PAR) on the short arm of the X chromosome, 1.3 Mb from the telomere, proximal to the pseudoautosomal genes CSF2RA and 113RA, and ANT2 has been previously assigned to the long arm of the X chromosome Xq. In this study, we used somatic cell hybrids containing different portions of the human X chromosome to confirm the localization of ANT2 to the long arm of the X chromosome and to assign it regionally to Xq24-q27. 13 refs., 1 fig.