Cerebrospinal fluid filtration in amyotrophic lateral sclerosis
Cerebrospinal fluid filtration in amyotrophic lateral sclerosis
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DOI：
10.1046/j.1468-1331.1999.650597.x
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发表时间：
1999-09-01
影响因子：
5.1
通讯作者：
Mamoli, B
中科院分区：
文献类型：
--
作者：
Finsterer, J;Mamoli, B
通过一项随机、对照和开放性研究，作者希望了解脑脊液（CSF）过滤是否对散发性肌萎缩侧索硬化症（SALS）患者有实质性获益。5名SALS患者，年龄51-75岁，接受利鲁唑治疗，每天进行CSF过滤，持续5天（A组）。另外5名年龄在52-70岁的SALS患者仅接受利鲁唑治疗（B组）。尽管第一组中的所有5名患者均报告了CSF滤过后的主观获益，但无论是A组还是B组，治疗5天后Norris评分、弗伦谢评分、肺活量、尺神经F波持续性以及肱二头肌和胫前肌的峰值比均未发生显著变化。总之，在5天内每天过滤200-250 ml CSF似乎对SALS患者没有实质性治疗效果。Eur J Neurol 6：597-600（C）1999 Lippincott威廉姆斯和威尔金斯。
By means of a randomized, controlled and open study the authors wanted to find out if cerebrospinal (CSF)-filtration was of substantial benefit to patients with sporadic amyotrophic lateral sclerosis (SALS). Five SALS patients, aged 51-75 years, being treated with riluzole underwent CSF-filtration daily over five days (group A). Five other SALS patients, aged 52-70 years, were treated only with riluzole (group B). Although all five patients in the first group reported a subjective benefit following CSF-filtration, the Norris score, the Frenchay score, the vital capacity, the ulnar nerve F-wave persistence and the peak-ratio of the brachial biceps and anterior tibial muscles did not change significantly after five days of therapy either in group A or in group B. In conclusion, filtration of 200-250 mi CSF daily, over five days, does not seem to have a substantial therapeutic effect in patients,vith SALS. Eur J Neurol 6:597-600 (C) 1999 Lippincott Williams & Wilkins.