Prevalence of osteoporosis and related lifestyle and metabolic factors of postmenopausal women and elderly men: A cross-sectional study in Gansu province, Northwestern of China.
Prevalence of osteoporosis and related lifestyle and metabolic factors of postmenopausal women and elderly men: A cross-sectional study in Gansu province, Northwestern of China.
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DOI：
10.1097/md.0000000000008294
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发表时间：
2017-10
期刊：
影响因子：
1.6
通讯作者：
Guo T
中科院分区：
文献类型：
--
作者：
Tian L;Yang R;Wei L;Liu J;Yang Y;Shao F;Ma W;Li T;Wang Y;Guo T
本研究的目的是调查甘肃省绝经后妇女和老年男性的骨质疏松患病率及其风险。这项横断面研究涉及甘肃省7个地区随机抽取的3359名绝经后妇女和3205名老年男性。使用双能 X 射线吸收测定法（DXA：Osteometer MediTech）在无应力前臂远端三分之一半径处测量面积骨矿物质密度 (BMD) (g/cm2)。分析了与骨质疏松症相关的因素。根据WHO标准，整个研究人群的骨质疏松患病率为绝经后女性9.65%，老年男性8.08%；骨质减少率为绝经后女性27.09%，老年男性26.68%。绝经后女性骨质疏松症的风险与年龄、绝经年龄、绝经持续时间、体重指数（BMI）、教育水平和饮酒量显着相关。在老年男性中，年龄、体重指数、当前吸烟、饮酒、体力活动和阳光照射与骨质疏松症相关。骨转换标志物骨钙素（OC）和I型胶原C端交联端肽（β-CTX）与男女骨密度呈负相关；血清 P 和 25(OH)D 与 BMD 没有显着相关性。血清钙仅对老年男性的骨密度有积极影响。介绍了甘肃省绝经后妇女和60岁以上男性骨质疏松患病情况。绝经后女性的骨质疏松症风险与年龄、绝经年龄、绝经年数、BMI 和教育水平显着相关。在老年男性中，年龄、体重指数和当前吸烟情况与骨质疏松症有关。这项研究还发现，较高的 OC 和 β-CTX 水平与较低的 BMD 相关。 25(OH)D、Ca、P 状态不佳与低 BMD 风险增加无关。
The aim of this study was to investigate the osteoporosis prevalence and the risks of postmenopausal women and elderly men in Gansu province. This cross-sectional study involved 3359 postmenopausal women and 3205 elderly males who were randomly selected from 7 areas in Gansu province. Areal bone mineral density (BMD) (g/cm2) was measured at the distal one-third radius of the nonstressed forearm using dual-energy X-ray absorptiometry (DXA: Osteometer MediTech). Factors related to osteoporosis were analyzed. The prevalence of osteoporosis in the entire study population was 9.65% for postmenopausal women and 8.08% for elderly males by WHO criteria, while the rate of osteopenia were 27.09% for postmenopausal women and 26.68% for elderly males. Risk of osteoporosis was significantly associated with age, menopause age, duration of menopause, body mass index (BMI), educational level, and alcohol consumption in postmenopausal women. In elderly men, age, BMI, current smoking, alcohol consumption, physical activity, and sun exposure were associated with osteoporosis. The bone turnover markers osteocalcin (OC) and C-terminal cross-linked telopeptides of type I collagen (β-CTX) were inversely correlated with BMD in both genders; serum P and 25(OH)D found no significant correlation with BMD. Serum Ca showed a positive effect on BMD in elderly men only. The osteoporosis prevalence of postmenopausal women and the men aged over 60 years in Gansu province is presented. Risk of osteoporosis was significantly associated with age, menopause age, year since menopause, BMI, and educational level in postmenopausal women. In elderly men, age, BMI, and current smoking were associated with osteoporosis. This study also found that higher OC and β-CTX level were associated with lower BMD. Poor 25(OH)D, Ca, P status were not associated with an increased risk of low BMD.