Cooperative Recognition of Internationally Disseminated Ceftriaxone-Resistant Neisseria gonorrhoeae Strain.
Cooperative Recognition of Internationally Disseminated Ceftriaxone-Resistant Neisseria gonorrhoeae Strain.
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DOI：
10.3201/eid2404.171873
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发表时间：
2018-04
影响因子：
11.8
通讯作者：
Whiley D
中科院分区：
文献类型：
--
作者：
Lahra MM;Martin I;Demczuk W;Jennison AV;Lee KI;Nakayama SI;Lefebvre B;Longtin J;Ward A;Mulvey MR;Wi T;Ohnishi M;Whiley D
在大多数情况下，头孢曲松仍然是淋病奈瑟菌感染患者的一线治疗。在最近在丹麦（GK124）和加拿大（47707）分离出类似菌株后，我们调查了耐头孢曲松FC428淋病奈瑟菌克隆在日本可能传播的情况。我们在澳大利亚报告了2例来自亚洲的异性恋男性FC428克隆病例。我们的生物信息学分析包括核心单核苷酸变异系统发育和硅分子分型；系统发育分析表明，5个分离株遗传亲缘关系密切。结果显示多位点序列为1903型；淋病奈瑟菌耐药序列分型（NG-STAR） 233；嵌合的penA等位基因编码改变A311V和T483S (penA-60.001)，与头孢曲松抗性相关。我们的结果提供了头孢曲松耐药淋病奈瑟菌国际传播的进一步证据。我们建议提高对这种耐药菌株国际传播的认识，加强监测，包括查明治疗失败和接触者，并加强数据的国际共享。
Ceftriaxone remains a first-line treatment for patients infected by Neisseria gonorrhoeae in most settings. We investigated the possible spread of a ceftriaxone-resistant FC428 N. gonorrhoeae clone in Japan after recent isolation of similar strains in Denmark (GK124) and Canada (47707). We report 2 instances of the FC428 clone in Australia in heterosexual men traveling from Asia. Our bioinformatic analyses included core single-nucleotide variation phylogeny and in silico molecular typing; phylogenetic analysis showed close genetic relatedness among all 5 isolates. Results showed multilocus sequence type 1903; N. gonorrhoeae sequence typing for antimicrobial resistance (NG-STAR) 233; and harboring of mosaic penA allele encoding alterations A311V and T483S (penA-60.001), associated with ceftriaxone resistance. Our results provide further evidence of international transmission of ceftriaxone-resistant N. gonorrhoeae. We recommend increasing awareness of international spread of this drug-resistant strain, strengthening surveillance to include identifying treatment failures and contacts, and strengthening international sharing of data.