Organ dysfunction, injury and failure in acute heart failure: from pathophysiology to diagnosis and management. A review on behalf of the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC).
Organ dysfunction, injury and failure in acute heart failure: from pathophysiology to diagnosis and management. A review on behalf of the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC).
复制标题
DOI：
10.1002/ejhf.872
复制
发表时间：
2017-07
影响因子：
18.2
通讯作者：
Mebazaa A
中科院分区：
文献类型：
--
作者：
Harjola VP;Mullens W;Banaszewski M;Bauersachs J;Brunner-La Rocca HP;Chioncel O;Collins SP;Doehner W;Filippatos GS;Flammer AJ;Fuhrmann V;Lainscak M;Lassus J;Legrand M;Masip J;Mueller C;Papp Z;Parissis J;Platz E;Rudiger A;Ruschitzka F;Schäfer A;Seferovic PM;Skouri H;Yilmaz MB;Mebazaa A
急性心力衰竭(AHF)患者常见器官损伤和损害，充血是器官功能损害的重要病理生理机制。充血是大多数AHF患者的主要临床特征；较小比例的患者出现外周低灌流或心源性休克。低灌注量会进一步恶化器官功能。AHF时靶器官(即心、肺、肾、肝、肠、脑)的损伤和功能障碍与死亡风险增加有关。减充血治疗后器官功能的改善与出院后死亡的风险较低有关。因此，器官功能障碍的预防和纠正代表了AHF的治疗目标，应该在临床试验中进行评估。具体预防、减少或逆转器官功能障碍的治疗策略仍有待确定和评估，以确定此类干预措施是否影响死亡率、发病率和以患者为中心的结果。这篇论文反映了专家们对AHF中器官损害的表现和处理的当前理解，并建议了未来研究的优先事项，以促进该领域的发展。
Organ injury and impairment are commonly observed in patients with acute heart failure (AHF), and congestion is an essential pathophysiological mechanism of impaired organ function. Congestion is the predominant clinical profile in most patients with AHF; a smaller proportion presents with peripheral hypoperfusion or cardiogenic shock. Hypoperfusion further deteriorates organ function. The injury and dysfunction of target organs (i.e. heart, lungs, kidneys, liver, intestine, brain) in the setting of AHF are associated with increased risk for mortality. Improvement in organ function after decongestive therapies has been associated with a lower risk for post-discharge mortality. Thus, the prevention and correction of organ dysfunction represent a therapeutic target of interest in AHF and should be evaluated in clinical trials. Treatment strategies that specifically prevent, reduce or reverse organ dysfunction remain to be identified and evaluated to determine if such interventions impact mortality, morbidity and patient-centred outcomes. This paper reflects current understanding among experts of the presentation and management of organ impairment in AHF and suggests priorities for future research to advance the field.
登录
查看更多内容
影响因子：
6.2
作者：
Collins, SP;Lindsell, CJ;Abraham, WT
通讯作者：
Abraham, WT
影响因子：
4.4
作者：
Al Deeb, Mohammad;Barbic, Skye;Barbic, David
通讯作者：
Barbic, David
影响因子：
39.3
作者：
Aissaoui, Nadia;Puymirat, Etienne;Danchin, Nicolas
通讯作者：
Danchin, Nicolas
影响因子：
3.2
作者：
Agostoni, Piergiuseppe;Cattadori, Gala;Apostolo, Anna
通讯作者：
Apostolo, Anna
DOI：
10.1016/s0735-1097(02)02896-6
发表时间：
2003-02-19
影响因子：
24
作者：
Adamson, PB;Magalski, A;Bennett, T
通讯作者：
Bennett, T