The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose.
The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose.
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DOI：
10.1016/j.jaci.2011.02.019
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发表时间：
2011-05
期刊：
影响因子：
--
通讯作者：
Platts-Mills TA
中科院分区：
文献类型：
--
作者：
Commins SP;James HR;Kelly LA;Pochan SL;Workman LJ;Perzanowski MS;Kocan KM;Fahy JV;Nganga LW;Ronmark E;Cooper PJ;Platts-Mills TA
在2009年，我们报告了一种新的形式的迟发性过敏反应的红肉，这是有关的血清IgE抗体的寡糖半乳糖-α-1，3-半乳糖（α-半乳糖）。这些患者中的大多数人多年来一直容忍肉类。这意味着，在成年生活中的一些接触刺激了这些IgE抗体的产生。调查这种IgE抗体反应的可能原因，重点是与蜱叮咬相关的证据，这在这些反应发生的地区很常见。使用与链霉亲和素ImmunoCAP结合的生物素化蛋白质和提取物进行血清测定。对蜱叮咬后的三名受试者进行的IgE抗体的前瞻性研究显示，α-gal的IgE增加了20倍或更高。其他证据包括i）蜱叮咬史与IgE对α-gal的强相关性（χ2=26.8，p<0.001），ii）这些IgE抗体在蜱Amblyomma americanum常见的地区常见的证据，和iii）IgE抗体对α-gal和IgE抗体对源自A的蛋白质的显著相关性。美洲型（rs=0.75，p<0.001）。这里提出的结果提供了证据，蜱叮咬是一个原因，或可能是唯一的原因，特异性IgE的α-半乳糖在美国的这个地区。致敏的受试者数量和α-gal的IgE抗体滴度都是惊人的。在这里，我们报告的第一个例子，反应的体外寄生虫引起的一种重要形式的食物过敏。
In 2009, we reported a novel form of delayed anaphylaxis to red meat, which is related to serum IgE antibodies to the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal). Most of these patients had tolerated meat for many years previously. The implication is that some exposure in adult life had stimulated the production of these IgE antibodies. To investigate possible causes of this IgE antibody response, focusing on evidence related to tick bites, which are common in the region where these reactions occur. Serum assays were carried out using biotinylated proteins and extracts bound to a streptavidin ImmunoCAP. Prospective studies on IgE antibodies in three subjects following tick bites showed an increase in IgE to alpha-gal of twenty-fold or greater. Other evidence included i) a strong correlation between histories of tick bites and IgE to alpha-gal (χ2=26.8, p<0.001), ii) evidence that these IgE antibodies are common in areas where the tick Amblyomma americanum is common, and iii) a significant correlation between IgE antibodies to alpha-gal and IgE antibodies to proteins derived from A. americanum (rs=0.75, p<0.001). The results presented here provide evidence that tick bites are a cause, or possibly the only cause, of IgE specific for alpha-gal in this area of the United States. Both the number of subjects becoming sensitized and the titer of IgE antibodies to alpha-gal are striking. Here we report the first example of a response to an ectoparasite giving rise to an important form of food allergy.
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影响因子：
14.2
作者：
Erwin, EA;Custis, NJ;Platts-Mills, TAE
通讯作者：
Platts-Mills, TAE
影响因子：
5.9
作者：
Beaudouin, E;Kanny, G;MoneretVautrin, DA
通讯作者：
MoneretVautrin, DA
影响因子：
2.1
作者：
BROWN, SJ;ASKENASE, PW
通讯作者：
ASKENASE, PW
DOI：
10.1073/pnas.0610012104
发表时间：
2007-01-09
影响因子：
11.1
作者：
Koike, Chihiro;Uddin, Monica;Goodman, Morris
通讯作者：
Goodman, Morris
影响因子：
158.5
作者：
Bonner, JA;Harari, PM;Ang, KK
通讯作者：
Ang, KK