beta-Aminopropionitrile prevents bleomycin-induced pulmonary fibrosis in the hamster.
beta-Aminopropionitrile prevents bleomycin-induced pulmonary fibrosis in the hamster.
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β-氨基丙腈可预防博莱霉素诱导的仓鼠肺纤维化。
DOI：
10.1164/arrd.1982.125.1.67
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Prockop,DJ
中科院分区：
文献类型：
--
作者：
Riley,DJ;Kerr,JS;Berg,RA;Ianni,BD;Pietra,GG;Edelman,NH;Prockop,DJ
β-氨基丙腈 (βAPN) 是一种防止组织中胶原蛋白积累的药物，评估了其在博来霉素诱导的仓鼠肺纤维化中防止胶原蛋白过度形成的能力。两组动物接受单次气管内剂量的博来霉素；其中一组每天注射两次 βAPN，持续 30 天。第三组接受气管内盐水，第四组接受盐水和βAPN。 30天后，我们测量了充满盐水的肺部的压力-容积曲线、胶原蛋白含量和纤维化程度。气管内注射博来霉素会增加胶原含量，减少肺体积，并产生纤维化，死亡率高达51%。对博来霉素治疗的动物施用βAPN可防止胶原蛋白过度积累并减少总蛋白，逆转体积减少，减少纤维化，并将死亡率提高至24%；单独使用 βAPN 对肺力学或胶原蛋白含量没有影响。博莱霉素诱导的肺纤维化的生化、功能和结构特征适合用 βAPN 进行控制。
β-Aminopropionitrile (βAPN), an agent that prevents collagen accumulation in tissues, was evaluated for its ability to prevent excess collagen formation in bleomycin-induced pulmonary fibrosis in the hamster. Two groups of animals received a single endotracheal dose of bleomycin; one of these was injected with βAPN twice daily for 30 days. A third group received endotracheal saline and a fourth group received saline and βAPN. After 30 days, we measured pressure-volume curves of saline-filled lungs, collagen content, and degree of fibrosis. Endotracheal bleomycin increased collagen content, decreased lung volume, and produced fibrosis and a mortality rate of 51%. The administration of βAPN to bleomycin-treated animals prevented excess collagen accumulation and diminished total protein, reversed volume diminution, produced less fibrosis, and improved the mortality rate to 24%; βAPN alone had no effect on lung mechanics or collagen content. The biochemical, functional, and structural features of bleomycin-induced lung fibrosis are amenable to control with βAPN.