Semisynthesis of 14C-labelled leupeptin.
Semisynthesis of 14C-labelled leupeptin.
复制标题
14C 标记的亮肽素的半合成。
DOI：
10.1248/cpb.30.2319
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发表时间：
1982
影响因子：
1.7
通讯作者：
S. Ishii
中科院分区：
文献类型：
--
作者：
T. Saino;T. Someno;H. Miyazaki;S. Ishii
^ C-Labelled leupeptin, Ac-L-[U-14C]-leucyl-L-leucyl-L-argininal, with a specific radioactivity of 20.9 mCi/mmol was prepared by a semisynthetic procedure in which L-leucyl-L-argininal dibutylacetal obtained by an enzymatic cleavage of leupeptin dibutyl-acetal with thermolysin was employed as a key compound. The chemical and radiochemical purities of the labelled leupeptin were found to be over 99% by high performance liquid chromatography using radioisotope and ultraviolet detectors.
