Ventricular myocardial catecholamines in primates.
Ventricular myocardial catecholamines in primates.
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灵长类动物心室心肌儿茶酚胺。
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
J. Cohn
中科院分区：
文献类型：
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作者：
G. Pierpont;E. Demaster;Stephanie Reynolds;Jonathan Pederson;J. Cohn
我们报告心肌儿茶酚胺水平测定灵长类脑室高压液相色谱与电化学检测。11只猕猴（4只恒河猴和7只食水猴）左心室去甲肾上腺素含量为1391 +/- 362 ng/gm (+/- sd)，从基底（最高）到顶点（最低）有一定的梯度。多巴胺和肾上腺素的浓度要低得多（分别为51.8 +/- 24.5 ng/gm和59.2 +/- 20.0 ng/gm），但在整个左心室的分布相似。去甲肾上腺素的浓度在动物之间有相当大的差异，但多巴胺/去甲肾上腺素的比例在给定的动物内非常一致，平均为3.7% +/- 1.4%。这些值可能表明人体中儿茶酚胺的正常浓度，并为解释疾病研究中获得的结果提供了基础。
We report myocardial catecholamine levels in primate ventricles assayed by high-pressure liquid chromatography with electrochemical detection. The norepinephrine content of the left ventricles of 11 monkeys (four rhesus and seven cynomolgus) was 1391 +/- 362 ng/gm (+/-SD) with a definite gradient from base (highest) to apex (lowest concentration). Dopamine and epinephrine were present in much lower concentrations (51.8 +/- 24.5 ng/gm and 59.2 +/- 20.0 ng/gm, respectively), but were similarly distributed throughout the left ventricle. There was considerable variation in norepinephrine concentration between animals, but the dopamine/norepinephrine ratio was very consistent within a given animal, averaging 3.7% +/- 1.4%. These values are probably indicative of what normal concentrations of catecholamines are likely to be in humans, and provide a basis for interpretation of results obtained in disease studies.