Remembering episodes: a selective role for the hippocampus during retrieval
Remembering episodes: a selective role for the hippocampus during retrieval
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DOI：
10.1038/80671
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发表时间：
2000-11-01
影响因子：
25
通讯作者：
Engel, SA
中科院分区：
文献类型：
--
作者：
Eldridge, LL;Knowlton, BT;Engel, SA
有些记忆与特定的时间和地点有关，使人能够重新体验最初的事件，而另一些记忆只伴随着熟悉的感觉。为了揭示这两种记忆的不同神经基础，我们使用事件相关功能磁共振成像测量了记忆提取过程中的大脑活动。我们发现，只有当检索伴随着有意识的回忆的学习情节时，海马体的活动增加。对于根据熟悉程度识别的项目或未识别的项目，海马活动没有增加。这些结果表明，海马选择性地支持情节记忆的提取。
Some memories are linked to a specific time and place, allowing one to re-experience the original event, whereas others are accompanied only by a feeling of familiarity. To uncover the distinct neural bases for these two types of memory, we measured brain activity during memory retrieval using event-related functional magnetic resonance imaging. We show that activity in the hippocampus increased only when retrieval was accompanied by conscious recollection of the learning episode. Hippocampal activity did not increase for items recognized based on familiarity or for unrecognized items. These results indicate that the hippocampus selectively supports the retrieval of episodic memories.