Inorganic arsenic exposure and type 2 diabetes mellitus in Mexico
Inorganic arsenic exposure and type 2 diabetes mellitus in Mexico
复制标题
DOI：
10.1016/j.envres.2007.03.004
复制
发表时间：
2007-07-01
影响因子：
8.3
通讯作者：
la Pena, Jorge Escobedo-de
中科院分区：
文献类型：
--
作者：
Coronado-Gonzalez, Jose Antonio;Del Razo, Luz Maria;la Pena, Jorge Escobedo-de
近年来，饮用水中的无机砷暴露与糖尿病有关。为了评估这种关系，作者在2003年进行了一项病例对照研究，研究地点是墨西哥北方墨西哥州的一个砷中毒流行区，糖尿病发病率很高。本分析包括200例病例和200例对照。这些病例是从该地区以前进行的一项横断面研究中获得的。根据美国糖尿病协会标准，两次空腹血糖值>= 126 mg/100 ml（>= 7.0 mmol/l）或有糖尿病史，并接受胰岛素或口服降糖药治疗，即可确诊糖尿病。在横断面研究中确定病例后，将下一个研究对象作为对照。无机砷暴露量通过尿中总砷浓度测定，采用双原子吸收分光光度法测定。尿中总砷浓度中等的受试者（63.5-104微克/克肌酐）有两倍高的风险患糖尿病（比值比= 2.16; 95%置信区间：1.23，3.79），但尿中总砷浓度较高的受试者的风险几乎高出3倍（比值比= 2.84; 95%置信区间：1.64，4.92）。这一数据提供了额外的证据表明，无机砷暴露可能是糖尿病。(c)2007年爱思唯尔公司All rights reserved.
Inorganic arsenic exposure in drinking water has been recently related to diabetes mellitus. To evaluate this relationship the authors conducted in 2003, a case-control study in an arseniasis-endemic region from Coahuila, a northern state of Mexico with a high incidence of diabetes. The present analysis includes 200 cases and 200 controls. Cases were obtained from a previous cross-sectional study conducted in that region. Diagnosis of diabetes was established following the American Diabetes Association criteria, with two fasting glucose values >= 126mg/100 ml (>= 7.0 mmol/l) or a history of diabetes treated with insulin or oral hypoglycemic agents. The next subject studied, subsequent to the identification of a case in the cross-sectional study was taken as control. Inorganic arsenic exposure was measured through total arsenic concentrations in urine, measured by hydride-generation atomic absorption spectrophotometry. Subjects with intermediate total arsenic concentration in urine (63.5-104 mu g/g creatinine) had two-fold higher risk of having diabetes (odds ratio = 2.16; 95% confidence interval: 1.23, 3.79), but the risk was almost three times greater in subjects with higher concentrations of total arsenic in urine (odds ratio = 2.84; 95% confidence interval: 1.64, 4.92). This data provides additional evidence that inorganic arsenic exposure may be diabetogenic. (c) 2007 Elsevier Inc. All rights reserved.