Posterior cingulate metabolic changes occur in Parkinson's disease patients without dementia
Posterior cingulate metabolic changes occur in Parkinson's disease patients without dementia
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DOI：
10.1016/j.neulet.2003.09.076
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发表时间：
2004-01-16
影响因子：
2.5
通讯作者：
Hanstock, CC
中科院分区：
文献类型：
--
作者：
Camicioli, RM;Korzan, JR;Hanstock, CC
帕金森病（PD）认知缺陷的基础尚不清楚。海马萎缩已在阿尔茨海默病 (AD) 和 PD 中得到证实。 AD 中后扣带回 (PCG) 中的 N-乙酰天冬氨酸 (NAA)/肌酸 (Cr) 比率降低，但 PD 中未知。体积磁共振 (MR) 成像（1.5 T）确定了 12 名非痴呆轻度至中度帕金森病患者（六名男性，六名女性）和 10 名对照者（五名男性，五名女性）的校正 HC 体积和 MR 波谱 (MRS) PCG 代谢物。年龄（PD = 60.6 岁，对照组 = 62.2；P = 0.62）、教育程度（PD = 14.1 岁，对照组 = 118；P = 0.89）和整体认知（简易精神状态考试分数：PD = 28.7，对照组 = 29.6；P = 0.14）没有差异。 PD 中仅召回率（CVLT-II，P = 0.046）和 NAA/Cr（PD = 1.53，对照 = 1.78；P = 0.03）下降。 PD 中的记忆力与 NAA/Cr 相关（r = 0.65，P = 0.02）。总之，PD 中发生扣带回代谢变化。 (C) 2003 Elsevier Ireland Ltd. 保留所有权利。
The basis for cognitive deficits in Parkinson's disease (PD) is unknown. Hippocampal atrophy has been shown in Alzheimer's disease (AD) and PD. N-Acetyl aspartate (NAA)/creatine (Cr) ratio in the posterior cingulate gyrus (PCG) is decreased in AD, but unknown in PD. Volumetric magnetic resonance (MR) imaging (at 1.5 T) determined corrected HC volume and MR spectroscopy (MRS) PCG metabolites in 12 non-demented mild to moderately affected PD patients (six male, six female) and ten controls (five male, five female). Age (PD = 60.6 years, control = 62.2; P = 0.62), education (PD = 14.1 years, controls = 118; P = 0.89) and global cognition (Mini-Mental State Exam score: PD = 28.7, controls = 29.6; P = 0.14) did not differ. Only recall (CVLT-II, P = 0.046) and NAA/Cr (PD = 1.53, controls = 1.78; P = 0.03) were decreased in PD. Memory correlated with NAA/Cr (r = 0.65, P = 0.02) in PD. In conclusion, cingulate metabolic changes occur in PD. (C) 2003 Elsevier Ireland Ltd. All rights reserved.