Coupling of autonomic and central events during sleep benefits declarative memory consolidation
Coupling of autonomic and central events during sleep benefits declarative memory consolidation
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DOI：
10.1016/j.nlm.2018.12.008
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发表时间：
2019-01-01
影响因子：
2.7
通讯作者：
Mednick, Sara C.
中科院分区：
文献类型：
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作者：
Naji, Mohsen;Krishnan, Giri P.;Mednick, Sara C.
虽然前脑认知和脑干自主神经中枢之间的解剖学通路是明确的，但睡眠期间的神经中枢相互作用及其对清醒表现的贡献尚不清楚。在这里，我们分析了清醒和白天睡眠期间通过脑电图（EEG）和心电图（ECG）的自主心脏搏动间期（RR间期）的同时中枢活动。我们确定了持续4-5秒的心电图活动爆发，并在非快速眼动睡眠（NREM）中占主导地位。使用NREM睡眠的基于事件的分析，我们发现增量（0.5-4 Hz）和西格玛（12-15 Hz）功率的增加以及心率爆发峰值前约5 s的慢振荡（0.5-1 Hz）密度的升高，以及迷走神经活动的激增，通过RR间期的高频（HF）分量进行评估。使用回归框架，我们表明，这些自主/中央事件（ACE）积极预测午睡后改善陈述性记忆任务后，控制的影响，纺锤波和缓慢振荡的睡眠期没有ACE。在记忆力表现和控制小睡之间没有发现这种关系。此外，NREM ACE与REM睡眠和非陈述性记忆任务中的学习呈负相关。这些结果提供了第一个证据，协调自主和中央事件在陈述性记忆巩固中发挥了重要作用。
While anatomical pathways between forebrain cognitive and brainstem autonomic nervous centers are well-defined, autonomic-central interactions during sleep and their contribution to waking performance are not understood. Here, we analyzed simultaneous central activity via electroencephalography (EEG) and autonomic heart beat-to-beat intervals (RR intervals) from electrocardiography (ECG) during wake and daytime sleep. We identified bursts of ECG activity that lasted 4-5 s and predominated in non-rapid-eye-movement sleep (NREM). Using event-based analysis of NREM sleep, we found an increase in delta (0.5-4 Hz) and sigma (12-15 Hz) power and an elevated density of slow oscillations (0.5-1 Hz) about 5 s prior to peak of the heart rate burst, as well as a surge in vagal activity, assessed by high-frequency (HF) component of RR intervals. Using regression framework, we show that these Autonomic/Central Events (ACE) positively predicted post-nap improvement in a declarative memory task after controlling for the effects of spindles and slow oscillations from sleep periods without ACE. No such relation was found between memory performance and a control nap. Additionally, NREM ACE negatively correlated with REM sleep and learning in a non-declarative memory task. These results provide the first evidence that coordinated autonomic and central events play a significant role in declarative memory consolidation.