Structural variants of heavy and light chains of atrial and ventricular myosins in hypertrophied human hearts
Structural variants of heavy and light chains of atrial and ventricular myosins in hypertrophied human hearts
复制标题
肥大的人类心脏中心房和心室肌球蛋白重链和轻链的结构变异
DOI：
10.1007/978-3-642-85326-5_17
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发表时间：
1983
影响因子：
--
通讯作者：
M. Schaub
中科院分区：
文献类型：
--
作者：
C. Tuchschmid;T. Srihari;H. Hirzel;M. Schaub
在人类心脏肥大中，肌球蛋白轻链补体的相对组成以及心房和心室中的组织特异性组成发生变化。为了支持最近的结果（P. Cummins [1982] Biochem. J., 205,195-204），我们还发现除了其自身的轻链补体之外，心室 VLC-2 和较小程度的 VLC-1 也出现在肥大的心房中。我们的新发现涉及肥厚心室中心房 ALC-1 的额外发生。我们进一步观察到，在成人肥厚心脏的心室和心房中，1 型轻链比 2 型轻链占优势。另一方面，在正常和肥大的心室或心房组织之间，由两种不同的蛋白酶从分离的肌球蛋白重链产生的总共约180种可区分肽的肽模式没有观察到差异。然而，正常心房和心室的肽模式存在许多差异，表明这两种心脏组织中肌球蛋白重链的一级结构不同。
In human cardiac hypertrophy the myosin light chain complement varies in its relative composition as well as in its tissue-specific composition in both atrium and ventricle. In support of recent results (P. Cummins [1982] Biochem. J., 205,195-204), we also found ventricular VLC-2 and to a lesser extent VLC-1 to occur in hypertrophied atrium in addition to its own light chain complement. Our new findings concern the additional occurrence of atrial ALC-1 in hypertrophied ventricle. We further observed a large predominance of light chain of type-1 over that of type-2 in both ventricle and atrium of adult hypertrophied hearts. On the other hand, no differences were observed in the peptide patterns containing a total of around 180 distinguishable peptides produced by two different proteinases from the isolated myosin heavy chains, between normal and hypertrophied ventricular or atrial tissues. However, a number of differences in the peptide patterns from normal atrium and ventricle indicates different primary structures of the myosin heavy chains in these two heart tissues.
兔心室肌球蛋白重链的两个分子变体的分离和表征。
DOI：
--
发表时间：
1982
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Chizzonite,RA;Everett,AW;Clark,WA;Jakovcic,S;Rabinowitz,M;Zak,R
通讯作者：
Zak,R
心脏同肌球蛋白之间的物种相关性。
DOI：
--
发表时间：
1982
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
ClarkJr,WA;Chizzonite,RA;Everett,AW;Rabinowitz,M;Zak,R
通讯作者：
Zak,R