Cytoarchitectonic subdivisions of the dorsolateral frontal cortex of the marmoset monkey (Callithrix jacchus), and their projections to dorsal visual areas
Cytoarchitectonic subdivisions of the dorsolateral frontal cortex of the marmoset monkey (Callithrix jacchus), and their projections to dorsal visual areas
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DOI：
10.1002/cne.20837
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发表时间：
2006-03-10
影响因子：
2.5
通讯作者：
Rosa, MGP
中科院分区：
文献类型：
--
作者：
Burman, KJ;Palmer, SM;Rosa, MGP
我们结合建筑方法（尼氏、细胞色素氧化酶和髓磷脂染色）和在纹外区域（第二视觉区域 [V2]、背内侧和背前区域 [DM、DA]、中颞区和中颞新月区 [MT、MTc] 以及后顶叶皮层 [区域] 注射荧光示踪剂，描述狨猴背外侧额区的组织。 7]）。细胞结构域 8 包括三个细分：8Av、8Ad 和 8B。腹外侧细分 8Av 形成额向“背侧流”投射的主要来源，与每个注入的视觉区域都有联系。 8Av 的细胞结构特征表明该细分对应于狨猴的额眼区域。区域 8 的中间细分 (8Ad) 具有到区域 7 的传出投射，而背内侧细分 (8B) 与纹外皮质很少或没有连接。区域 46 位于 8Av 区域的头外侧，与内侧纹外区域（DM、DA 和区域 7）以及 MT 有实质性联系，而 8Av 外侧皮质（区域 12/45）主要投射到 MT 和 MTc。喙内侧前额叶（区域 9）和额极（区域 10）区域几乎没有纹外投射。最后，背侧区域 6 (6d) 的细胞对 DM、MT 和 MTc 具有稀疏的投影，对 DA 和区域 7 具有强烈的投影。这些结果阐明了灵长类额叶皮层进化发展的各个方面，并为使用狨猴模型进一步研究认知功能奠定了基础。
We describe the organization of the dorsolateral frontal areas in marmoset monkeys using a combination of architectural methods (Nissl, cytochrome oxidase, and myelin stains) and injections of fluorescent tracers in extrastriate areas (the second visual area [V2], the dorsomedial and dorsoanterior areas [DM, DA], the middle temporal area and middle temporal crescent [MT, MTc], and the posterior parietal cortex [area 7]). Cytoarchitectural field 8 comprises three subdivisions: 8Av, 8Ad, and 8B. The ventrolateral subdivision, 8Av, forms the principal source of frontal projections to the "dorsal stream," having connections with each of the injected visual areas. The cytoarchitectural characteristics of 8Av suggest that this subdivision corresponds to the marmoset's frontal eye field. The intermediate subdivision of area 8 (8Ad) has efferent projections to area 7, while the dorsomedial subdivision (8B) has few or no connections with extrastriate cortex. Area 46, located rostrolateral to area 8Av, has substantial connections with the medial extrastriate areas (DM, DA, and area 7) and with MT, while the cortex lateral to 8Av (area 12/45) projects primarily to MT and to the MTc. The rostromedial prefrontal (area 9) and frontopolar (area 10) regions have very few extrastriate projections. Finally, cells in dorsal area 6 (6d) have sparse projections to DM, MT, and the MTc, as well as strong projections to DA and to area 7. These results illuminate aspects of the evolutionary development of the primate frontal cortex, and serve as a basis for further research into cognitive functions using a marmoset model.