FIRING CHANGES IN CELLS OF NUCLEUS MEDIALIS DORSALIS ASSOCIATED WITH DELAYED RESPONSE BEHAVIOR
FIRING CHANGES IN CELLS OF NUCLEUS MEDIALIS DORSALIS ASSOCIATED WITH DELAYED RESPONSE BEHAVIOR
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DOI：
10.1016/0006-8993(73)90517-9
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发表时间：
1973-01-01
期刊：
影响因子：
2.9
通讯作者：
ALEXANDER, GE
中科院分区：
文献类型：
--
作者：
FUSTER, JM;ALEXANDER, GE
猴子被训练去执行延迟反应（DR）任务。一个视觉提示——将食物放在两个测试对象之一的下面——被延迟了18秒，在此期间，测试对象被隐藏起来，遥不可及。在延迟结束时，玩家可以选择这些物品，如果选择正确，还可以获得奖励。单单位活动记录从丘脑核在DR表现。主要研究了背内侧核的小窝部和大蜂窝部。通常观察到自发表现出节律性放电的单位，特别是在MD大细胞部。根据放电频率变化的时间模式，区分出6种不同类型的单元。在MD取样的所有单位中，大约有一半的pars parvoculularis在延迟期间显示出持续的放电升高。这些发现与另一项关于前额皮质区域的研究结果相当，该区域与MD（细胞旁部）有关。与行为任务相关的放电变化被解释为MD与前额皮质在DR表现中的功能性参与的表现。从解剖学、电生理学和行为学的研究中可以得到的证据来讨论这种参与的可能性质。
Monkeys were trained to perform a delayed response (DR) task. A visual cue—placement of food under one of two test objects—was succeded by a delay of 18 sec, during which the test objects were concealed and out of reach. At the end of the delay, the objects were made accessible for choice and, if the choice was correct, for reward.Single unit activity was recorded from thalamic nuclei during DR performance. The parvo- and magnocelularis portions of the nucleus medialis dorsalis (MD) were principally explored. Units spontaneously exhibiting rhytmic firing were commonly observed, particularly in MD pars magnocellularis. According to temporal patterns of firing frequency changes during DR trials, 6 different types of units were distinguished. Approximately one-half of all the units sampled in MD, pars parvocellularis, showed sustained elevations of discharge during the delay. These findings are comparable to those made in a separate study of the prefrontal cortical area to which MD, pars parvocellularis, is connected.The firing changes correlated with the behavioral task are interpreted as manifestations of a functional involvement of MD, together with the prefrontal cortex, in DR performance. The possible nature of this involvement is discussed in relation to the available evidence from anatomical, electrophysiological and behavioral research.