Human-placenta-derived mesenchymal stem cells inhibit proliferation and function of allogeneic immune cells
Human-placenta-derived mesenchymal stem cells inhibit proliferation and function of allogeneic immune cells
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人胎盘来源的间充质干细胞抑制同种异体免疫细胞的增殖和功能
DOI：
10.1007/s00441-007-0504-5
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发表时间：
2007-12-01
影响因子：
3.6
通讯作者：
Mao, Ning
中科院分区：
文献类型：
--
作者：
Li, Changdong;Zhang, Weiyuan;Mao, Ning
有证据表明，间充质干细胞（MSCs）代表了一个有希望的细胞群体，支持新的临床细胞疗法。目前，骨髓是MSCs的主要来源，但其分化能力随着年龄的增长而下降。我们已经从人胎盘中鉴定出可能的新型多系间充质细胞。除了它们的多系分化外，它们在体外对成人外周血（PB）和脐带血（UCB）中T淋巴细胞的增殖有直接的免疫抑制作用。这种免疫调节特性强烈暗示它们在同种异体移植物移植中有潜在的应用。由于胎盘和UCB可以从同一供体获得，因此胎盘是与UCB来源的造血干细胞联合移植的间充质干细胞的一个有吸引力的来源，以减少受体发生移植物抗宿主病的可能性。然而，它们调节免疫系统的方式尚不清楚。在这项研究中，我们研究了人胎盘间充质干细胞对不同亚型的UCB-derived和PB-derived T淋巴细胞的影响。
Evidence has emerged that mesenchymal stem cells (MSCs) represent a promising cell population for supporting new clinical cellular therapies. Currently, bone marrow represents the main source of MSCs, but their differentiation capacity declines with age. We have identified possible novel multilineage mesenchymal cells from human placenta. In addition to their multilineage differentiation, they have a direct immunosuppressive effect on proliferation of T lymphocytes from human adult peripheral blood (PB) and umbilical cord blood (UCB) in vitro. This immunoregulatory feature strongly implies that they have a potential application in allograft transplantation. Since placenta and UCB can be obtained from the same donor, placenta is an attractive source of MSCs for co-transplantation in conjunction with UCB-derived hematopoietic stem cells to reduce the potential of graft-versus-host disease in recipients. However, the way that they modulate the immune system is unclear. In this investigation, we have addressed the effects of human placental MSCs on various subtypes of UCB-derived and PB-derived T lymphocytes.