Assessment of cerebral oxygenation during prolonged simulated driving using near infrared spectroscopy: its implications for fatigue development
Assessment of cerebral oxygenation during prolonged simulated driving using near infrared spectroscopy: its implications for fatigue development
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使用近红外光谱法评估长时间模拟驾驶过程中的脑氧合：其对疲劳发展的影响
DOI：
10.1007/s00421-009-1122-6
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发表时间：
2009-10-01
影响因子：
3
通讯作者：
Wang, Yan
中科院分区：
文献类型：
--
作者：
Li, Zengyong;Zhang, Ming;Wang, Yan
有关健康人长时间驾驶期间大脑氧合的信息可能有助于解释中枢疲劳的原因和发展及其对皮质活动的影响。本研究的目的是调查长时间驾驶任务期间脑氧合的时间过程。四十名健康男性受试者随机分为两组：任务组（Task）和对照组（CNL）。所有受试者在实验前均需充分休息。对于任务组，受试者被要求执行 3 小时的模拟驾驶任务。在整个实验过程中，使用近红外光谱从左额叶监测脑氧合信号。与静息值相比，驾驶任务开始时 HbO2 (ΔCHbO2) 和 HbT (ΔCHbT) 浓度显着增加 (p< 0.01)。研究发现，与 CNL 相比，任务组在驾驶 3 小时后的脑氧饱和度显着降低（F= 16.95，p<0.001）。此外，在任务后阶段，任务组和 CNL 之间的选择性反应时间存在显着差异 (p= 0.023)。结果表明，脑氧合与精神压力密切相关。脑氧饱和度的降低可能表明脑氧输送减少，这可能是影响长时间驾驶中枢疲劳发生的重要因素。
Information on cerebral oxygenation during prolonged driving in healthy humans may help to explain the cause and development of central fatigue and its effects on cortex activities. The objective of this study is to investigate the time course of cerebral oxygenation during a prolonged driving task. Forty healthy male subjects were randomly divided into two groups: task group (Task) and control group (CNL). All subjects were required to rest well prior to the experiment. For the task group, subjects were required to perform the simulated driving task for 3 h. Cerebral oxygenation signal was monitored from the left frontal lobe using near infrared spectroscopy throughout the entire experiment. Significant increases in the concentrations of HbO2(ΔCHbO2) and HbT (ΔCHbT) were recorded at the start of driving task compared with the resting value (p< 0.01). The cerebral oxygen saturation in the Task group was found to be significantly lower following three hours of driving compared with that in the CNL (F= 16.95,p< 0.001). In addition, a significant difference in selective reaction time was observed between the Task group and CNL during the post-task period (p= 0.023). The results demonstrated that the cerebral oxygenation is closely related to the mental stress. The decrease in the cerebral oxygen saturation may indicate reduced cerebral oxygen delivery, and this may be an important factor affecting central fatigue development during prolonged driving.